STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HCRTOrexin; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Belongs to the orexin family. (130 aa)    
Predicted Functional Partners:
HCRTR1
Hypocretin receptor 1; Belongs to the G-protein coupled receptor 1 family.
   
 0.999
HCRTR2
Hypocretin receptor 2; Belongs to the G-protein coupled receptor 1 family.
   
 0.998
HLA-DQB1
HLA class II histocompatibility antigen, DQ beta 1 chain isoform X3.
    
 
 0.949
NPS
Neuropeptide S.
     
 0.922
PMCH
Pro-MCH.
   
 
 0.921
ENSPTRP00000087048
annotation not available
   
 
 0.880
PMCHL1
Pro-MCH variant; Belongs to the melanin-concentrating hormone family.
   
 
 0.880
GHRL
GHRL isoform 10.
     
 0.849
POMC
Proopiomelanocortin.
   
  
 0.839
AGRP
Agouti related neuropeptide.
      
 0.812
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.