STAT5A protein (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EGFR	ERBB4	ENSPTRP00000069741	ENSPTRP00000063299	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.951
EGFR	JAK1	ENSPTRP00000069741	ENSPTRP00000001425	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase.	0.969
EGFR	JAK2	ENSPTRP00000069741	ENSPTRP00000082180	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase.	0.986
EGFR	STAT3	ENSPTRP00000069741	ENSPTRP00000091410	Receptor protein-tyrosine kinase.	Signal transducer and activator of transcription.	0.998
EGFR	STAT5A	ENSPTRP00000069741	ENSPTRP00000015668	Receptor protein-tyrosine kinase.	Signal transducer and activator of transcription.	0.992
EGFR	STAT5B	ENSPTRP00000069741	ENSPTRP00000089134	Receptor protein-tyrosine kinase.	Signal transducer and activator of transcription.	0.990
EGFR	TYK2	ENSPTRP00000069741	ENSPTRP00000049016	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase.	0.437
EP300	STAT3	ENSPTRP00000024841	ENSPTRP00000091410	E1A binding protein p300.	Signal transducer and activator of transcription.	0.998
EP300	STAT5A	ENSPTRP00000024841	ENSPTRP00000015668	E1A binding protein p300.	Signal transducer and activator of transcription.	0.988
EP300	STAT5B	ENSPTRP00000024841	ENSPTRP00000089134	E1A binding protein p300.	Signal transducer and activator of transcription.	0.978
ERBB4	EGFR	ENSPTRP00000063299	ENSPTRP00000069741	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.951
ERBB4	JAK1	ENSPTRP00000063299	ENSPTRP00000001425	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase.	0.423
ERBB4	JAK2	ENSPTRP00000063299	ENSPTRP00000082180	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase.	0.484
ERBB4	STAT3	ENSPTRP00000063299	ENSPTRP00000091410	Receptor protein-tyrosine kinase.	Signal transducer and activator of transcription.	0.717
ERBB4	STAT5A	ENSPTRP00000063299	ENSPTRP00000015668	Receptor protein-tyrosine kinase.	Signal transducer and activator of transcription.	0.987
ERBB4	STAT5B	ENSPTRP00000063299	ENSPTRP00000089134	Receptor protein-tyrosine kinase.	Signal transducer and activator of transcription.	0.984
ERBB4	TYK2	ENSPTRP00000063299	ENSPTRP00000049016	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase.	0.423
IL2RA	IL2RB	ENSPTRP00000003829	ENSPTRP00000024676	Interleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.	Interleukin-2 receptor subunit beta; Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (By similarity).	0.998
IL2RA	JAK1	ENSPTRP00000003829	ENSPTRP00000001425	Interleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.	Tyrosine-protein kinase.	0.988
IL2RA	JAK2	ENSPTRP00000003829	ENSPTRP00000082180	Interleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.	Tyrosine-protein kinase.	0.910