| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AQP4 | CASP3 | ENSPTRP00000016898 | ENSPTRP00000054330 | AQP4 isoform 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. | 0.454 |
| AQP4 | CD68 | ENSPTRP00000016898 | ENSPTRP00000014826 | AQP4 isoform 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. | CD68 isoform 1. | 0.566 |
| AQP4 | DES | ENSPTRP00000016898 | ENSPTRP00000082534 | AQP4 isoform 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. | DES isoform 1; Belongs to the intermediate filament family. | 0.481 |
| AQP4 | GFAP | ENSPTRP00000016898 | ENSPTRP00000062393 | AQP4 isoform 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. | Glial fibrillary acidic protein; Belongs to the intermediate filament family. | 0.834 |
| AQP4 | VIM | ENSPTRP00000016898 | ENSPTRP00000003945 | AQP4 isoform 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. | Vimentin; Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. | 0.481 |
| CASP3 | AQP4 | ENSPTRP00000054330 | ENSPTRP00000016898 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. | AQP4 isoform 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. | 0.454 |
| CASP3 | CD68 | ENSPTRP00000054330 | ENSPTRP00000014826 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. | CD68 isoform 1. | 0.692 |
| CASP3 | DES | ENSPTRP00000054330 | ENSPTRP00000082534 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. | DES isoform 1; Belongs to the intermediate filament family. | 0.677 |
| CASP3 | ENSPTRP00000086254 | ENSPTRP00000054330 | ENSPTRP00000086254 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. | Microtubule-associated protein tau. | 0.855 |
| CASP3 | GFAP | ENSPTRP00000054330 | ENSPTRP00000062393 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. | Glial fibrillary acidic protein; Belongs to the intermediate filament family. | 0.828 |
| CASP3 | MAPT | ENSPTRP00000054330 | ENSPTRP00000015840 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. | Microtubule-associated protein tau; Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabili [...] | 0.855 |
| CASP3 | NES | ENSPTRP00000054330 | ENSPTRP00000002483 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. | NES isoform 1; Belongs to the intermediate filament family. | 0.702 |
| CASP3 | VIM | ENSPTRP00000054330 | ENSPTRP00000003945 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. | Vimentin; Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. | 0.767 |
| CD68 | AQP4 | ENSPTRP00000014826 | ENSPTRP00000016898 | CD68 isoform 1. | AQP4 isoform 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. | 0.566 |
| CD68 | CASP3 | ENSPTRP00000014826 | ENSPTRP00000054330 | CD68 isoform 1. | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. | 0.692 |
| CD68 | GFAP | ENSPTRP00000014826 | ENSPTRP00000062393 | CD68 isoform 1. | Glial fibrillary acidic protein; Belongs to the intermediate filament family. | 0.805 |
| DES | AQP4 | ENSPTRP00000082534 | ENSPTRP00000016898 | DES isoform 1; Belongs to the intermediate filament family. | AQP4 isoform 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. | 0.481 |
| DES | CASP3 | ENSPTRP00000082534 | ENSPTRP00000054330 | DES isoform 1; Belongs to the intermediate filament family. | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. | 0.677 |
| DES | GFAP | ENSPTRP00000082534 | ENSPTRP00000062393 | DES isoform 1; Belongs to the intermediate filament family. | Glial fibrillary acidic protein; Belongs to the intermediate filament family. | 0.852 |
| DES | INA | ENSPTRP00000082534 | ENSPTRP00000005120 | DES isoform 1; Belongs to the intermediate filament family. | Internexin neuronal intermediate filament protein, alpha; Belongs to the intermediate filament family. | 0.729 |
