PHB protein (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

PHB

Prohibitin. (272 aa)

Predicted Functional Partners:

PHB2

0.999

RAF1

0.891

ERLIN2

0.867

STOM

0.853

LOC748850

0.815

HDAC1

0.815

ERLIN1

0.809

STOML2

0.777

SPG7

0.746

AFG3L2

0.731

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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structured XML interaction data, according to the 'PSI-MI' data standard

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... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFG3L2	PHB	ENSPTRP00000016808	ENSPTRP00000015927	AFG3 like matrix AAA peptidase subunit 2.	Prohibitin.	0.731
AFG3L2	PHB2	ENSPTRP00000016808	ENSPTRP00000091437	AFG3 like matrix AAA peptidase subunit 2.	Prohibitin.	0.835
AFG3L2	SPG7	ENSPTRP00000016808	ENSPTRP00000063563	AFG3 like matrix AAA peptidase subunit 2.	Spastic paraplegia 7 (Pure and complicated autosomal recessive).	0.943
AFG3L2	STOM	ENSPTRP00000016808	ENSPTRP00000083351	AFG3 like matrix AAA peptidase subunit 2.	STOM isoform 3.	0.573
AFG3L2	STOML2	ENSPTRP00000016808	ENSPTRP00000087492	AFG3 like matrix AAA peptidase subunit 2.	Stomatin (EPB72)-like 2.	0.603
ERLIN1	ERLIN2	ENSPTRP00000004991	ENSPTRP00000034509	ER lipid raft associated 1.	ER lipid raft associated 2.	0.993
ERLIN1	PHB	ENSPTRP00000004991	ENSPTRP00000015927	ER lipid raft associated 1.	Prohibitin.	0.809
ERLIN1	STOM	ENSPTRP00000004991	ENSPTRP00000083351	ER lipid raft associated 1.	STOM isoform 3.	0.411
ERLIN2	ERLIN1	ENSPTRP00000034509	ENSPTRP00000004991	ER lipid raft associated 2.	ER lipid raft associated 1.	0.993
ERLIN2	PHB	ENSPTRP00000034509	ENSPTRP00000015927	ER lipid raft associated 2.	Prohibitin.	0.867
ERLIN2	PHB2	ENSPTRP00000034509	ENSPTRP00000091437	ER lipid raft associated 2.	Prohibitin.	0.564
ERLIN2	STOM	ENSPTRP00000034509	ENSPTRP00000083351	ER lipid raft associated 2.	STOM isoform 3.	0.485
HDAC1	PHB	ENSPTRP00000075891	ENSPTRP00000015927	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	Prohibitin.	0.815
HDAC1	PHB2	ENSPTRP00000075891	ENSPTRP00000091437	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	Prohibitin.	0.719
LOC748850	PHB	ENSPTRP00000067224	ENSPTRP00000015927	HDAC2 isoform 9.	Prohibitin.	0.815
LOC748850	PHB2	ENSPTRP00000067224	ENSPTRP00000091437	HDAC2 isoform 9.	Prohibitin.	0.719
PHB	AFG3L2	ENSPTRP00000015927	ENSPTRP00000016808	Prohibitin.	AFG3 like matrix AAA peptidase subunit 2.	0.731
PHB	ERLIN1	ENSPTRP00000015927	ENSPTRP00000004991	Prohibitin.	ER lipid raft associated 1.	0.809
PHB	ERLIN2	ENSPTRP00000015927	ENSPTRP00000034509	Prohibitin.	ER lipid raft associated 2.	0.867
PHB	HDAC1	ENSPTRP00000015927	ENSPTRP00000075891	Prohibitin.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.815