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The next version of STRING is ready for use in your analyses: updated networks across STRING newly available directed regulatory networks a new typed view showing functional, physical, and regulatory edges in one network new clustering options and cluster-based layouts … and much more!
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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GRIN2CGRIN2C isoform 4. (1240 aa)    
Predicted Functional Partners:
GRIN2A
Glutamate receptor ionotropic, NMDA 2A; Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition; channels containing GRIN1 and GRIN2A have higher sensitivity to glutamate and faster kineti [...]
   
0.997
GRIN1
Glutamate receptor, ionotropic, N-methyl D-aspartate 1.
   
0.996
GRIN2B
Glutamate ionotropic receptor NMDA type subunit 2B.
     
0.989
DLG4
Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.
    
 0.983
GRIN3A
GRIN3A isoform 1.
   
0.946
GRIN2D
GRIN2D isoform 1.
  
  
0.934
CALML5
Calmodulin like 5.
    
 0.926
CALML3
Calmodulin like 3; Belongs to the calmodulin family.
    
 0.925
CALM3
Calmodulin 1 (Phosphorylase kinase, delta); Belongs to the calmodulin family.
    
 0.924
CALML6
Calmodulin like 6.
    
 0.920
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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