OTOP2 protein (Pan troglodytes) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

OTOP2

OTOP2 isoform 1. (562 aa)

Predicted Functional Partners:

TMEM128

0.925

DRD5

0.727

PCDH15

0.706

CD4

0.559

LOC465127

0.533

USH1C

0.521

OC90

0.457

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD4	OTOP2	ENSPTRP00000054833	ENSPTRP00000016350	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	OTOP2 isoform 1.	0.559
DRD5	OTOP2	ENSPTRP00000053705	ENSPTRP00000016350	D(1B) dopamine receptor.	OTOP2 isoform 1.	0.727
DRD5	TMEM128	ENSPTRP00000053705	ENSPTRP00000088833	D(1B) dopamine receptor.	Transmembrane protein 128.	0.890
LOC465127	OTOP2	ENSPTRP00000079338	ENSPTRP00000016350	Dopamine receptor D5 pseudogene.	OTOP2 isoform 1.	0.533
LOC465127	TMEM128	ENSPTRP00000079338	ENSPTRP00000088833	Dopamine receptor D5 pseudogene.	Transmembrane protein 128.	0.660
OC90	OTOP2	ENSPTRP00000035206	ENSPTRP00000016350	OC90 isoform 1.	OTOP2 isoform 1.	0.457
OTOP2	CD4	ENSPTRP00000016350	ENSPTRP00000054833	OTOP2 isoform 1.	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	0.559
OTOP2	DRD5	ENSPTRP00000016350	ENSPTRP00000053705	OTOP2 isoform 1.	D(1B) dopamine receptor.	0.727
OTOP2	LOC465127	ENSPTRP00000016350	ENSPTRP00000079338	OTOP2 isoform 1.	Dopamine receptor D5 pseudogene.	0.533
OTOP2	OC90	ENSPTRP00000016350	ENSPTRP00000035206	OTOP2 isoform 1.	OC90 isoform 1.	0.457
OTOP2	PCDH15	ENSPTRP00000016350	ENSPTRP00000078994	OTOP2 isoform 1.	Protocadherin related 15.	0.706
OTOP2	TMEM128	ENSPTRP00000016350	ENSPTRP00000088833	OTOP2 isoform 1.	Transmembrane protein 128.	0.925
OTOP2	USH1C	ENSPTRP00000016350	ENSPTRP00000048221	OTOP2 isoform 1.	USH1C isoform 4.	0.521
PCDH15	OTOP2	ENSPTRP00000078994	ENSPTRP00000016350	Protocadherin related 15.	OTOP2 isoform 1.	0.706
PCDH15	TMEM128	ENSPTRP00000078994	ENSPTRP00000088833	Protocadherin related 15.	Transmembrane protein 128.	0.705
PCDH15	USH1C	ENSPTRP00000078994	ENSPTRP00000048221	Protocadherin related 15.	USH1C isoform 4.	0.945
TMEM128	DRD5	ENSPTRP00000088833	ENSPTRP00000053705	Transmembrane protein 128.	D(1B) dopamine receptor.	0.890
TMEM128	LOC465127	ENSPTRP00000088833	ENSPTRP00000079338	Transmembrane protein 128.	Dopamine receptor D5 pseudogene.	0.660
TMEM128	OTOP2	ENSPTRP00000088833	ENSPTRP00000016350	Transmembrane protein 128.	OTOP2 isoform 1.	0.925
TMEM128	PCDH15	ENSPTRP00000088833	ENSPTRP00000078994	Transmembrane protein 128.	Protocadherin related 15.	0.705