RPTOR protein (Pan troglodytes) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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Assay-based Predictions

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co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1S1	ATG13	ENSPTRP00000019444	ENSPTRP00000079168	AKT1 substrate 1 (Proline-rich).	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.	0.949
AKT1S1	MLST8	ENSPTRP00000019444	ENSPTRP00000070104	AKT1 substrate 1 (Proline-rich).	MLST8 isoform 3.	0.997
AKT1S1	MTOR	ENSPTRP00000019444	ENSPTRP00000000280	AKT1 substrate 1 (Proline-rich).	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.999
AKT1S1	RPS6KB1	ENSPTRP00000019444	ENSPTRP00000016085	AKT1 substrate 1 (Proline-rich).	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	0.986
AKT1S1	RPS6KB2	ENSPTRP00000019444	ENSPTRP00000006810	AKT1 substrate 1 (Proline-rich).	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	0.974
AKT1S1	RPTOR	ENSPTRP00000019444	ENSPTRP00000016590	AKT1 substrate 1 (Proline-rich).	Regulatory associated protein of MTOR, complex 1.	0.999
AKT1S1	RRAGA	ENSPTRP00000019444	ENSPTRP00000035579	AKT1 substrate 1 (Proline-rich).	Ras-related GTP binding A.	0.942
AKT1S1	RRAGB	ENSPTRP00000019444	ENSPTRP00000047390	AKT1 substrate 1 (Proline-rich).	Ras related GTP binding B.	0.916
AKT1S1	RRAGC	ENSPTRP00000019444	ENSPTRP00000000985	AKT1 substrate 1 (Proline-rich).	Ras related GTP binding C.	0.956
AKT1S1	RRAGD	ENSPTRP00000019444	ENSPTRP00000080706	AKT1 substrate 1 (Proline-rich).	Ras-related GTP binding D.	0.951
ATG13	AKT1S1	ENSPTRP00000079168	ENSPTRP00000019444	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.	AKT1 substrate 1 (Proline-rich).	0.949
ATG13	MLST8	ENSPTRP00000079168	ENSPTRP00000070104	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.	MLST8 isoform 3.	0.988
ATG13	MTOR	ENSPTRP00000079168	ENSPTRP00000000280	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.987
ATG13	RPTOR	ENSPTRP00000079168	ENSPTRP00000016590	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.	Regulatory associated protein of MTOR, complex 1.	0.992
ATG13	RRAGA	ENSPTRP00000079168	ENSPTRP00000035579	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.	Ras-related GTP binding A.	0.664
ATG13	RRAGB	ENSPTRP00000079168	ENSPTRP00000047390	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.	Ras related GTP binding B.	0.664
ATG13	RRAGC	ENSPTRP00000079168	ENSPTRP00000000985	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.	Ras related GTP binding C.	0.646
ATG13	RRAGD	ENSPTRP00000079168	ENSPTRP00000080706	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.	Ras-related GTP binding D.	0.646
MLST8	AKT1S1	ENSPTRP00000070104	ENSPTRP00000019444	MLST8 isoform 3.	AKT1 substrate 1 (Proline-rich).	0.997
MLST8	ATG13	ENSPTRP00000070104	ENSPTRP00000079168	MLST8 isoform 3.	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.	0.988