| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CHMP2A | HGS | ENSPTRP00000065330 | ENSPTRP00000016628 | Charged multivesicular body protein 2A. | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | 0.975 |
| CHMP2A | STAM | ENSPTRP00000065330 | ENSPTRP00000003953 | Charged multivesicular body protein 2A. | Signal transducing adaptor molecule (SH3 domain and ITAM motif) 1. | 0.690 |
| CHMP2A | TSG101 | ENSPTRP00000065330 | ENSPTRP00000062068 | Charged multivesicular body protein 2A. | Tumor susceptibility 101. | 0.906 |
| CHMP2A | UBAP1 | ENSPTRP00000065330 | ENSPTRP00000043955 | Charged multivesicular body protein 2A. | UBAP1 isoform 4. | 0.741 |
| CHMP2A | UBC | ENSPTRP00000065330 | ENSPTRP00000050925 | Charged multivesicular body protein 2A. | Polyubiquitin-C; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] | 0.649 |
| CHMP2A | VPS28-2 | ENSPTRP00000065330 | ENSPTRP00000077768 | Charged multivesicular body protein 2A. | VPS28 isoform 16; Belongs to the VPS28 family. | 0.958 |
| EGFR | EPS15 | ENSPTRP00000069741 | ENSPTRP00000001250 | Receptor protein-tyrosine kinase. | Epidermal growth factor receptor pathway substrate 15. | 0.988 |
| EGFR | EPS15L1 | ENSPTRP00000069741 | ENSPTRP00000018168 | Receptor protein-tyrosine kinase. | Epidermal growth factor receptor pathway substrate 15 like 1. | 0.979 |
| EGFR | HGS | ENSPTRP00000069741 | ENSPTRP00000016628 | Receptor protein-tyrosine kinase. | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | 0.967 |
| EGFR | STAM | ENSPTRP00000069741 | ENSPTRP00000003953 | Receptor protein-tyrosine kinase. | Signal transducing adaptor molecule (SH3 domain and ITAM motif) 1. | 0.651 |
| EGFR | STAM2 | ENSPTRP00000069741 | ENSPTRP00000076329 | Receptor protein-tyrosine kinase. | Signal transducing adaptor molecule (SH3 domain and ITAM motif) 2. | 0.867 |
| EGFR | UBC | ENSPTRP00000069741 | ENSPTRP00000050925 | Receptor protein-tyrosine kinase. | Polyubiquitin-C; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] | 0.881 |
| EPS15 | EGFR | ENSPTRP00000001250 | ENSPTRP00000069741 | Epidermal growth factor receptor pathway substrate 15. | Receptor protein-tyrosine kinase. | 0.988 |
| EPS15 | EPS15L1 | ENSPTRP00000001250 | ENSPTRP00000018168 | Epidermal growth factor receptor pathway substrate 15. | Epidermal growth factor receptor pathway substrate 15 like 1. | 0.990 |
| EPS15 | HGS | ENSPTRP00000001250 | ENSPTRP00000016628 | Epidermal growth factor receptor pathway substrate 15. | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | 0.978 |
| EPS15 | STAM | ENSPTRP00000001250 | ENSPTRP00000003953 | Epidermal growth factor receptor pathway substrate 15. | Signal transducing adaptor molecule (SH3 domain and ITAM motif) 1. | 0.712 |
| EPS15 | STAM2 | ENSPTRP00000001250 | ENSPTRP00000076329 | Epidermal growth factor receptor pathway substrate 15. | Signal transducing adaptor molecule (SH3 domain and ITAM motif) 2. | 0.771 |
| EPS15 | UBC | ENSPTRP00000001250 | ENSPTRP00000050925 | Epidermal growth factor receptor pathway substrate 15. | Polyubiquitin-C; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] | 0.952 |
| EPS15L1 | EGFR | ENSPTRP00000018168 | ENSPTRP00000069741 | Epidermal growth factor receptor pathway substrate 15 like 1. | Receptor protein-tyrosine kinase. | 0.979 |
| EPS15L1 | EPS15 | ENSPTRP00000018168 | ENSPTRP00000001250 | Epidermal growth factor receptor pathway substrate 15 like 1. | Epidermal growth factor receptor pathway substrate 15. | 0.990 |
