HRH4 protein (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARRB1	GNB1	ENSPTRP00000043134	ENSPTRP00000067330	ARRB1 isoform 1.	Guanine nucleotide binding protein (G protein), beta polypeptide 1.	0.789
ARRB1	GNG2	ENSPTRP00000043134	ENSPTRP00000065345	ARRB1 isoform 1.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.616
ARRB1	HRH4	ENSPTRP00000043134	ENSPTRP00000016888	ARRB1 isoform 1.	Histamine receptor H4; Belongs to the G-protein coupled receptor 1 family.	0.499
CSF1	HRH4	ENSPTRP00000070067	ENSPTRP00000016888	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	Histamine receptor H4; Belongs to the G-protein coupled receptor 1 family.	0.540
GNAI1	GNAI2	ENSPTRP00000071974	ENSPTRP00000025802	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1.	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2.	0.999
GNAI1	GNAI3	ENSPTRP00000071974	ENSPTRP00000001821	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1.	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3.	0.999
GNAI1	GNB1	ENSPTRP00000071974	ENSPTRP00000067330	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1.	Guanine nucleotide binding protein (G protein), beta polypeptide 1.	0.997
GNAI1	GNG2	ENSPTRP00000071974	ENSPTRP00000065345	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.992
GNAI1	HRH4	ENSPTRP00000071974	ENSPTRP00000016888	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1.	Histamine receptor H4; Belongs to the G-protein coupled receptor 1 family.	0.762
GNAI2	GNAI1	ENSPTRP00000025802	ENSPTRP00000071974	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2.	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1.	0.999
GNAI2	GNAI3	ENSPTRP00000025802	ENSPTRP00000001821	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2.	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3.	0.999
GNAI2	GNB1	ENSPTRP00000025802	ENSPTRP00000067330	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2.	Guanine nucleotide binding protein (G protein), beta polypeptide 1.	0.997
GNAI2	GNG2	ENSPTRP00000025802	ENSPTRP00000065345	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.975
GNAI2	HRH4	ENSPTRP00000025802	ENSPTRP00000016888	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2.	Histamine receptor H4; Belongs to the G-protein coupled receptor 1 family.	0.460
GNAI3	GNAI1	ENSPTRP00000001821	ENSPTRP00000071974	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3.	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1.	0.999
GNAI3	GNAI2	ENSPTRP00000001821	ENSPTRP00000025802	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3.	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2.	0.999
GNAI3	GNB1	ENSPTRP00000001821	ENSPTRP00000067330	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3.	Guanine nucleotide binding protein (G protein), beta polypeptide 1.	0.997
GNAI3	GNG2	ENSPTRP00000001821	ENSPTRP00000065345	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.977
GNAI3	HRH4	ENSPTRP00000001821	ENSPTRP00000016888	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3.	Histamine receptor H4; Belongs to the G-protein coupled receptor 1 family.	0.623
GNB1	ARRB1	ENSPTRP00000067330	ENSPTRP00000043134	Guanine nucleotide binding protein (G protein), beta polypeptide 1.	ARRB1 isoform 1.	0.789