STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SMAD7Mothers against decapentaplegic homolog. (491 aa)    
Predicted Functional Partners:
SMURF1
E3 ubiquitin-protein ligase.
    
 0.999
TGFBR1
Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
   
 0.999
SMURF2
E3 ubiquitin-protein ligase.
    
 0.999
NEDD4L
NEDD4L isoform 6.
    
 0.996
YAP1
Yes-associated protein 1.
    
 0.994
RNF111
RNF111 isoform 5.
   
 0.980
SMAD2
Mothers against decapentaplegic homolog.
   
0.978
SMAD9
Mothers against decapentaplegic homolog.
   
0.973
SMAD5
Mothers against decapentaplegic homolog.
   
0.970
SMAD6
Mothers against decapentaplegic homolog.
  
 
0.968
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.