STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ME2Malic enzyme. (581 aa)    
Predicted Functional Partners:
FH
Fumarate hydratase.
  
 
 0.983
PC
Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
   
 0.977
MDH2
Malate dehydrogenase.
  
 0.958
LDHA
L-lactate dehydrogenase A chain.
  
 0.955
PDHB
Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
  
 
 0.953
LOC464999
LOW QUALITY PROTEIN: L-lactate dehydrogenase A chain-like.
  
 0.953
PKLR
Pyruvate kinase; Belongs to the pyruvate kinase family.
  
 0.948
LOC104002294
LOW QUALITY PROTEIN: pyruvate kinase PKM-like.
  
 0.948
PKM
Pyruvate kinase; Belongs to the pyruvate kinase family.
  
 0.948
MDH1
Malate dehydrogenase.
  
 0.945
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: medium (46%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.