| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ENSPTRP00000079420 | PIAS4 | ENSPTRP00000079420 | ENSPTRP00000017489 | annotation not available | Protein inhibitor of activated STAT protein 4. | 0.976 |
| ENSPTRP00000079420 | RNF168 | ENSPTRP00000079420 | ENSPTRP00000086137 | annotation not available | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] | 0.401 |
| ENSPTRP00000079420 | SUMO1-2 | ENSPTRP00000079420 | ENSPTRP00000084189 | annotation not available | Small ubiquitin-related modifier. | 0.945 |
| ENSPTRP00000079420 | SUMO3-2 | ENSPTRP00000079420 | ENSPTRP00000086080 | annotation not available | Small ubiquitin-related modifier. | 0.955 |
| ENSPTRP00000079420 | TP53 | ENSPTRP00000079420 | ENSPTRP00000014836 | annotation not available | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.940 |
| ENSPTRP00000079420 | UBE2I | ENSPTRP00000079420 | ENSPTRP00000012969 | annotation not available | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. | 0.870 |
| PIAS4 | ENSPTRP00000079420 | ENSPTRP00000017489 | ENSPTRP00000079420 | Protein inhibitor of activated STAT protein 4. | annotation not available | 0.976 |
| PIAS4 | RNF168 | ENSPTRP00000017489 | ENSPTRP00000086137 | Protein inhibitor of activated STAT protein 4. | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] | 0.964 |
| PIAS4 | STAT1 | ENSPTRP00000017489 | ENSPTRP00000090934 | Protein inhibitor of activated STAT protein 4. | Signal transducer and activator of transcription. | 0.960 |
| PIAS4 | STAT4 | ENSPTRP00000017489 | ENSPTRP00000079832 | Protein inhibitor of activated STAT protein 4. | Signal transducer and activator of transcription. | 0.957 |
| PIAS4 | STAT5A | ENSPTRP00000017489 | ENSPTRP00000015668 | Protein inhibitor of activated STAT protein 4. | Signal transducer and activator of transcription. | 0.955 |
| PIAS4 | STAT5B | ENSPTRP00000017489 | ENSPTRP00000089134 | Protein inhibitor of activated STAT protein 4. | Signal transducer and activator of transcription. | 0.955 |
| PIAS4 | SUMO1-2 | ENSPTRP00000017489 | ENSPTRP00000084189 | Protein inhibitor of activated STAT protein 4. | Small ubiquitin-related modifier. | 0.985 |
| PIAS4 | SUMO3-2 | ENSPTRP00000017489 | ENSPTRP00000086080 | Protein inhibitor of activated STAT protein 4. | Small ubiquitin-related modifier. | 0.983 |
| PIAS4 | TP53 | ENSPTRP00000017489 | ENSPTRP00000014836 | Protein inhibitor of activated STAT protein 4. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.967 |
| PIAS4 | UBE2I | ENSPTRP00000017489 | ENSPTRP00000012969 | Protein inhibitor of activated STAT protein 4. | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. | 0.985 |
| RNF168 | ENSPTRP00000079420 | ENSPTRP00000086137 | ENSPTRP00000079420 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] | annotation not available | 0.401 |
| RNF168 | PIAS4 | ENSPTRP00000086137 | ENSPTRP00000017489 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] | Protein inhibitor of activated STAT protein 4. | 0.964 |
| RNF168 | SUMO1-2 | ENSPTRP00000086137 | ENSPTRP00000084189 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] | Small ubiquitin-related modifier. | 0.594 |
| RNF168 | SUMO3-2 | ENSPTRP00000086137 | ENSPTRP00000086080 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] | Small ubiquitin-related modifier. | 0.489 |
