| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CYP17A1 | CYP1A1 | ENSPTRP00000069568 | ENSPTRP00000058539 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. | 0.916 |
| CYP17A1 | CYP2E1 | ENSPTRP00000069568 | ENSPTRP00000005465 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | Cytochrome P450 family 2 subfamily E member 1; Belongs to the cytochrome P450 family. | 0.920 |
| CYP17A1 | CYP3A4 | ENSPTRP00000069568 | ENSPTRP00000081767 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | Cytochrome P450 family 3 subfamily A member 4. | 0.937 |
| CYP17A1 | HSD11B1L | ENSPTRP00000069568 | ENSPTRP00000017581 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | Hydroxysteroid 11-beta dehydrogenase 1 like. | 0.918 |
| CYP17A1 | HSD17B12 | ENSPTRP00000069568 | ENSPTRP00000006113 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | Hydroxysteroid (17-beta) dehydrogenase 12; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.914 |
| CYP17A1 | HSD17B8 | ENSPTRP00000069568 | ENSPTRP00000030804 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | Hydroxysteroid (17-beta) dehydrogenase 8. | 0.935 |
| CYP17A1 | LOC745345 | ENSPTRP00000069568 | ENSPTRP00000071445 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | CYP21A2 isoform 1; Belongs to the cytochrome P450 family. | 0.924 |
| CYP1A1 | CYP17A1 | ENSPTRP00000058539 | ENSPTRP00000069568 | Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | 0.916 |
| CYP1A1 | CYP2A7 | ENSPTRP00000058539 | ENSPTRP00000018915 | Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. | CYP2A6 isoform 1; Belongs to the cytochrome P450 family. | 0.925 |
| CYP1A1 | CYP2D6 | ENSPTRP00000058539 | ENSPTRP00000042793 | Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. | Cytochrome P450 2D6; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids, steroids and retinoids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA). Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 20-hydroxyeicosatetraenoic acid ethanolamide (20-HETE-EA) and 8,9-, 11,12-, and 14,15-epoxyei [...] | 0.934 |
| CYP1A1 | CYP2E1 | ENSPTRP00000058539 | ENSPTRP00000005465 | Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. | Cytochrome P450 family 2 subfamily E member 1; Belongs to the cytochrome P450 family. | 0.940 |
| CYP1A1 | CYP3A4 | ENSPTRP00000058539 | ENSPTRP00000081767 | Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. | Cytochrome P450 family 3 subfamily A member 4. | 0.958 |
| CYP1A1 | HSD11B1L | ENSPTRP00000058539 | ENSPTRP00000017581 | Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. | Hydroxysteroid 11-beta dehydrogenase 1 like. | 0.918 |
| CYP1A1 | HSD17B12 | ENSPTRP00000058539 | ENSPTRP00000006113 | Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. | Hydroxysteroid (17-beta) dehydrogenase 12; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.913 |
| CYP1A1 | HSD17B8 | ENSPTRP00000058539 | ENSPTRP00000030804 | Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. | Hydroxysteroid (17-beta) dehydrogenase 8. | 0.926 |
| CYP1A1 | LOC101058187 | ENSPTRP00000058539 | ENSPTRP00000048703 | Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. | CYP2A13 isoform 1; Belongs to the cytochrome P450 family. | 0.924 |
| CYP2A7 | CYP1A1 | ENSPTRP00000018915 | ENSPTRP00000058539 | CYP2A6 isoform 1; Belongs to the cytochrome P450 family. | Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. | 0.925 |
| CYP2A7 | CYP2D6 | ENSPTRP00000018915 | ENSPTRP00000042793 | CYP2A6 isoform 1; Belongs to the cytochrome P450 family. | Cytochrome P450 2D6; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids, steroids and retinoids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA). Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 20-hydroxyeicosatetraenoic acid ethanolamide (20-HETE-EA) and 8,9-, 11,12-, and 14,15-epoxyei [...] | 0.940 |
| CYP2A7 | CYP2E1 | ENSPTRP00000018915 | ENSPTRP00000005465 | CYP2A6 isoform 1; Belongs to the cytochrome P450 family. | Cytochrome P450 family 2 subfamily E member 1; Belongs to the cytochrome P450 family. | 0.933 |
| CYP2A7 | CYP3A4 | ENSPTRP00000018915 | ENSPTRP00000081767 | CYP2A6 isoform 1; Belongs to the cytochrome P450 family. | Cytochrome P450 family 3 subfamily A member 4. | 0.944 |
