C3 protein (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C2	C3	ENSPTRP00000076687	ENSPTRP00000017648	Complement factor B Ba fragment; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes (By similarity).	Complement component 3.	0.992
C2	C5	ENSPTRP00000076687	ENSPTRP00000036418	Complement factor B Ba fragment; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes (By similarity).	Complement C5.	0.867
C2	CD46	ENSPTRP00000076687	ENSPTRP00000081199	Complement factor B Ba fragment; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes (By similarity).	CD46 isoform 5.	0.528
C2	CFHR1	ENSPTRP00000076687	ENSPTRP00000044519	Complement factor B Ba fragment; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes (By similarity).	T0196413 isoform 1.	0.772
C2	CFI	ENSPTRP00000076687	ENSPTRP00000053358	Complement factor B Ba fragment; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes (By similarity).	Complement factor I; Belongs to the peptidase S1 family.	0.852
C2	CFP	ENSPTRP00000076687	ENSPTRP00000037513	Complement factor B Ba fragment; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes (By similarity).	Complement factor properdin.	0.754
C2	CR1	ENSPTRP00000076687	ENSPTRP00000067654	Complement factor B Ba fragment; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes (By similarity).	CR1 isoform 2.	0.455
C2	LOC462577	ENSPTRP00000076687	ENSPTRP00000064661	Complement factor B Ba fragment; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes (By similarity).	C4B isoform 1.	0.774
C3	C2	ENSPTRP00000017648	ENSPTRP00000076687	Complement component 3.	Complement factor B Ba fragment; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes (By similarity).	0.992
C3	C3AR1	ENSPTRP00000017648	ENSPTRP00000007901	Complement component 3.	Complement C3a receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.971
C3	C5	ENSPTRP00000017648	ENSPTRP00000036418	Complement component 3.	Complement C5.	0.973
C3	CD46	ENSPTRP00000017648	ENSPTRP00000081199	Complement component 3.	CD46 isoform 5.	0.966
C3	CFHR1	ENSPTRP00000017648	ENSPTRP00000044519	Complement component 3.	T0196413 isoform 1.	0.978
C3	CFI	ENSPTRP00000017648	ENSPTRP00000053358	Complement component 3.	Complement factor I; Belongs to the peptidase S1 family.	0.996
C3	CFP	ENSPTRP00000017648	ENSPTRP00000037513	Complement component 3.	Complement factor properdin.	0.993
C3	CR1	ENSPTRP00000017648	ENSPTRP00000067654	Complement component 3.	CR1 isoform 2.	0.956
C3	ITGAM	ENSPTRP00000017648	ENSPTRP00000013737	Complement component 3.	Integrin subunit alpha M; Belongs to the integrin alpha chain family.	0.977
C3	LOC462577	ENSPTRP00000017648	ENSPTRP00000064661	Complement component 3.	C4B isoform 1.	0.972
C3AR1	C3	ENSPTRP00000007901	ENSPTRP00000017648	Complement C3a receptor 1; Belongs to the G-protein coupled receptor 1 family.	Complement component 3.	0.971
C3AR1	C5	ENSPTRP00000007901	ENSPTRP00000036418	Complement C3a receptor 1; Belongs to the G-protein coupled receptor 1 family.	Complement C5.	0.968