| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| HIPK2 | PIN1 | ENSPTRP00000033846 | ENSPTRP00000017779 | Homeodomain interacting protein kinase 2. | Peptidyl-prolyl cis-trans isomerase. | 0.839 |
| HIPK2 | PML | ENSPTRP00000033846 | ENSPTRP00000012429 | Homeodomain interacting protein kinase 2. | PML isoform 6. | 0.869 |
| HIPK2 | TP53 | ENSPTRP00000033846 | ENSPTRP00000014836 | Homeodomain interacting protein kinase 2. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.997 |
| IRF3 | PIN1 | ENSPTRP00000065398 | ENSPTRP00000017779 | Interferon regulatory factor 3. | Peptidyl-prolyl cis-trans isomerase. | 0.982 |
| MYC | PIN1 | ENSPTRP00000075568 | ENSPTRP00000017779 | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). | Peptidyl-prolyl cis-trans isomerase. | 0.724 |
| MYC | PLK1 | ENSPTRP00000075568 | ENSPTRP00000093799 | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). | Serine/threonine-protein kinase PLK. | 0.801 |
| MYC | PML | ENSPTRP00000075568 | ENSPTRP00000012429 | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). | PML isoform 6. | 0.818 |
| MYC | TP53 | ENSPTRP00000075568 | ENSPTRP00000014836 | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.890 |
| NCF4 | PIN1 | ENSPTRP00000073827 | ENSPTRP00000017779 | Neutrophil cytosolic factor 4. | Peptidyl-prolyl cis-trans isomerase. | 0.771 |
| NCF4 | PRKCB | ENSPTRP00000073827 | ENSPTRP00000013479 | Neutrophil cytosolic factor 4. | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | 0.944 |
| PIN1 | HIPK2 | ENSPTRP00000017779 | ENSPTRP00000033846 | Peptidyl-prolyl cis-trans isomerase. | Homeodomain interacting protein kinase 2. | 0.839 |
| PIN1 | IRF3 | ENSPTRP00000017779 | ENSPTRP00000065398 | Peptidyl-prolyl cis-trans isomerase. | Interferon regulatory factor 3. | 0.982 |
| PIN1 | MYC | ENSPTRP00000017779 | ENSPTRP00000075568 | Peptidyl-prolyl cis-trans isomerase. | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). | 0.724 |
| PIN1 | NCF4 | ENSPTRP00000017779 | ENSPTRP00000073827 | Peptidyl-prolyl cis-trans isomerase. | Neutrophil cytosolic factor 4. | 0.771 |
| PIN1 | PLK1 | ENSPTRP00000017779 | ENSPTRP00000093799 | Peptidyl-prolyl cis-trans isomerase. | Serine/threonine-protein kinase PLK. | 0.730 |
| PIN1 | PML | ENSPTRP00000017779 | ENSPTRP00000012429 | Peptidyl-prolyl cis-trans isomerase. | PML isoform 6. | 0.801 |
| PIN1 | POLR2D | ENSPTRP00000017779 | ENSPTRP00000021299 | Peptidyl-prolyl cis-trans isomerase. | Polymerase (RNA) II (DNA directed) polypeptide D. | 0.791 |
| PIN1 | PRKCB | ENSPTRP00000017779 | ENSPTRP00000013479 | Peptidyl-prolyl cis-trans isomerase. | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | 0.753 |
| PIN1 | SYAP1 | ENSPTRP00000017779 | ENSPTRP00000037179 | Peptidyl-prolyl cis-trans isomerase. | Synapse associated protein 1. | 0.784 |
| PIN1 | TP53 | ENSPTRP00000017779 | ENSPTRP00000014836 | Peptidyl-prolyl cis-trans isomerase. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.886 |
