STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NACC1Nucleus accumbens associated 1, BEN and BTB (POZ) domain containing. (527 aa)    
Predicted Functional Partners:
POLR2C
Polymerase (RNA) II (DNA directed) polypeptide C, 33kDa.
    
 0.894
LOC740780
Cytochrome c oxidase subunit 7C, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane [...]
      
 0.825
COX7C
Cytochrome c oxidase subunit VIIc.
      
 0.825
RPL37A
Ribosomal protein L37a.
    
 
 0.813
SCAF1
SCAF1 isoform 1.
   
    0.801
FBXL19
F-box and leucine rich repeat protein 19.
   
  0.801
RPL22
Ribosomal protein L22.
      
 0.785
RPS2
Ribosomal protein S2; Belongs to the universal ribosomal protein uS5 family.
   
 0.711
GADD45GIP1
Growth arrest and DNA-damage-inducible, gamma interacting protein 1.
    
 
 0.708
HDAC4
Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
   
 0.693
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.