EPS15L1 protein (Pan troglodytes) - STRING interaction network

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Score

EPS15L1

Epidermal growth factor receptor pathway substrate 15 like 1. (910 aa)

Predicted Functional Partners:

ITSN2

0.992

EGFR

0.992

EPN1

0.987

EPN3

0.977

EPN2

0.974

STON2

0.952

AP2S1

0.952

AP2A1

0.947

HGS

0.935

EPS15

0.934

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AP2A1	AP2S1	ENSPTRP00000068470	ENSPTRP00000088940	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.998
AP2A1	EGFR	ENSPTRP00000068470	ENSPTRP00000069741	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Receptor protein-tyrosine kinase.	0.899
AP2A1	EPN1	ENSPTRP00000068470	ENSPTRP00000019816	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	EPN1 isoform 5.	0.922
AP2A1	EPN2	ENSPTRP00000068470	ENSPTRP00000068433	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	EPN2 isoform 5.	0.921
AP2A1	EPN3	ENSPTRP00000068470	ENSPTRP00000086315	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	EPN3 isoform 1.	0.914
AP2A1	EPS15	ENSPTRP00000068470	ENSPTRP00000001250	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Epidermal growth factor receptor pathway substrate 15.	0.989
AP2A1	EPS15L1	ENSPTRP00000068470	ENSPTRP00000018168	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Epidermal growth factor receptor pathway substrate 15 like 1.	0.947
AP2A1	HGS	ENSPTRP00000068470	ENSPTRP00000016628	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	0.826
AP2A1	ITSN2	ENSPTRP00000068470	ENSPTRP00000020124	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	ITSN2 isoform 1.	0.948
AP2A1	STON2	ENSPTRP00000068470	ENSPTRP00000011219	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	STON2 isoform 1; Belongs to the Stoned B family.	0.716
AP2S1	AP2A1	ENSPTRP00000088940	ENSPTRP00000068470	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.998
AP2S1	EGFR	ENSPTRP00000088940	ENSPTRP00000069741	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	Receptor protein-tyrosine kinase.	0.524
AP2S1	EPN1	ENSPTRP00000088940	ENSPTRP00000019816	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	EPN1 isoform 5.	0.696
AP2S1	EPN2	ENSPTRP00000088940	ENSPTRP00000068433	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	EPN2 isoform 5.	0.693
AP2S1	EPN3	ENSPTRP00000088940	ENSPTRP00000086315	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	EPN3 isoform 1.	0.692
AP2S1	EPS15	ENSPTRP00000088940	ENSPTRP00000001250	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	Epidermal growth factor receptor pathway substrate 15.	0.956
AP2S1	EPS15L1	ENSPTRP00000088940	ENSPTRP00000018168	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	Epidermal growth factor receptor pathway substrate 15 like 1.	0.952
AP2S1	HGS	ENSPTRP00000088940	ENSPTRP00000016628	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	0.633
AP2S1	ITSN2	ENSPTRP00000088940	ENSPTRP00000020124	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	ITSN2 isoform 1.	0.982
AP2S1	STON2	ENSPTRP00000088940	ENSPTRP00000011219	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	STON2 isoform 1; Belongs to the Stoned B family.	0.823