| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AP2S1 | EGFR | ENSPTRP00000088940 | ENSPTRP00000069741 | AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. | Receptor protein-tyrosine kinase. | 0.601 |
| AP2S1 | EPN1 | ENSPTRP00000088940 | ENSPTRP00000019816 | AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. | EPN1 isoform 5. | 0.795 |
| AP2S1 | EPN2 | ENSPTRP00000088940 | ENSPTRP00000068433 | AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. | EPN2 isoform 5. | 0.789 |
| AP2S1 | EPN3 | ENSPTRP00000088940 | ENSPTRP00000086315 | AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. | EPN3 isoform 1. | 0.743 |
| AP2S1 | EPS15 | ENSPTRP00000088940 | ENSPTRP00000001250 | AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. | Epidermal growth factor receptor pathway substrate 15. | 0.982 |
| AP2S1 | EPS15L1 | ENSPTRP00000088940 | ENSPTRP00000018168 | AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. | Epidermal growth factor receptor pathway substrate 15 like 1. | 0.982 |
| AP2S1 | GRB2 | ENSPTRP00000088940 | ENSPTRP00000016382 | AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. | Growth factor receptor-bound protein 2. | 0.665 |
| AP2S1 | HGS | ENSPTRP00000088940 | ENSPTRP00000016628 | AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | 0.630 |
| AP2S1 | ITSN2 | ENSPTRP00000088940 | ENSPTRP00000020124 | AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. | ITSN2 isoform 1. | 0.972 |
| AP2S1 | STON2 | ENSPTRP00000088940 | ENSPTRP00000011219 | AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. | STON2 isoform 1; Belongs to the Stoned B family. | 0.969 |
| EGFR | AP2S1 | ENSPTRP00000069741 | ENSPTRP00000088940 | Receptor protein-tyrosine kinase. | AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. | 0.601 |
| EGFR | EPN1 | ENSPTRP00000069741 | ENSPTRP00000019816 | Receptor protein-tyrosine kinase. | EPN1 isoform 5. | 0.962 |
| EGFR | EPN2 | ENSPTRP00000069741 | ENSPTRP00000068433 | Receptor protein-tyrosine kinase. | EPN2 isoform 5. | 0.943 |
| EGFR | EPN3 | ENSPTRP00000069741 | ENSPTRP00000086315 | Receptor protein-tyrosine kinase. | EPN3 isoform 1. | 0.814 |
| EGFR | EPS15 | ENSPTRP00000069741 | ENSPTRP00000001250 | Receptor protein-tyrosine kinase. | Epidermal growth factor receptor pathway substrate 15. | 0.988 |
| EGFR | EPS15L1 | ENSPTRP00000069741 | ENSPTRP00000018168 | Receptor protein-tyrosine kinase. | Epidermal growth factor receptor pathway substrate 15 like 1. | 0.979 |
| EGFR | GRB2 | ENSPTRP00000069741 | ENSPTRP00000016382 | Receptor protein-tyrosine kinase. | Growth factor receptor-bound protein 2. | 0.999 |
| EGFR | HGS | ENSPTRP00000069741 | ENSPTRP00000016628 | Receptor protein-tyrosine kinase. | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | 0.967 |
| EGFR | ITSN2 | ENSPTRP00000069741 | ENSPTRP00000020124 | Receptor protein-tyrosine kinase. | ITSN2 isoform 1. | 0.806 |
| EGFR | STON2 | ENSPTRP00000069741 | ENSPTRP00000011219 | Receptor protein-tyrosine kinase. | STON2 isoform 1; Belongs to the Stoned B family. | 0.426 |
