STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FKBP8Peptidylprolyl isomerase. (413 aa)    
Predicted Functional Partners:
BCL2
BCL2 apoptosis regulator.
   
 
 0.956
EGLN1
EGLN1 isoform 1.
   
 
 0.911
HSP90AA1
Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...]
   
 0.909
RPTOR
Regulatory associated protein of MTOR, complex 1.
    
 
 0.872
HSP90AB1
HSP90AB1 isoform 1.
   
 0.863
MLST8
MLST8 isoform 3.
   
 
 0.862
AKT1S1
AKT1 substrate 1 (Proline-rich).
   
  
 0.828
MAP1LC3A
Microtubule associated protein 1 light chain 3 alpha.
   
  
 0.812
BCL2L1
BCL2L1 isoform 6.
   
 
 0.763
MTOR
Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.
    
 
 0.754
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.