| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AMACR | HPN | ENSPTRP00000073870 | ENSPTRP00000018535 | Alpha-methylacyl-CoA racemase isoform X2. | HPN isoform 1; Belongs to the peptidase S1 family. | 0.665 |
| F3 | HGF | ENSPTRP00000040007 | ENSPTRP00000072810 | Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. | Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. | 0.403 |
| F3 | HPN | ENSPTRP00000040007 | ENSPTRP00000018535 | Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. | HPN isoform 1; Belongs to the peptidase S1 family. | 0.504 |
| HGF | F3 | ENSPTRP00000072810 | ENSPTRP00000040007 | Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. | Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. | 0.403 |
| HGF | HPN | ENSPTRP00000072810 | ENSPTRP00000018535 | Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. | HPN isoform 1; Belongs to the peptidase S1 family. | 0.704 |
| HGF | LOC104003639 | ENSPTRP00000072810 | ENSPTRP00000063078 | Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. | Guanine nucleotide-binding protein G(s) subunit alpha. | 0.477 |
| HGF | MET | ENSPTRP00000072810 | ENSPTRP00000083162 | Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] | 0.999 |
| HGF | MST1R | ENSPTRP00000072810 | ENSPTRP00000025788 | Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. | Macrophage stimulating 1 receptor. | 0.905 |
| HGF | SPINT1 | ENSPTRP00000072810 | ENSPTRP00000011835 | Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. | SPINT1 isoform 2. | 0.848 |
| HGF | SPINT2 | ENSPTRP00000072810 | ENSPTRP00000065532 | Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. | T0106202 isoform 2. | 0.781 |
| HPN | AMACR | ENSPTRP00000018535 | ENSPTRP00000073870 | HPN isoform 1; Belongs to the peptidase S1 family. | Alpha-methylacyl-CoA racemase isoform X2. | 0.665 |
| HPN | F3 | ENSPTRP00000018535 | ENSPTRP00000040007 | HPN isoform 1; Belongs to the peptidase S1 family. | Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. | 0.504 |
| HPN | HGF | ENSPTRP00000018535 | ENSPTRP00000072810 | HPN isoform 1; Belongs to the peptidase S1 family. | Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. | 0.704 |
| HPN | IGLL5 | ENSPTRP00000018535 | ENSPTRP00000060622 | HPN isoform 1; Belongs to the peptidase S1 family. | IGLL5 isoform 1. | 0.828 |
| HPN | LOC104003639 | ENSPTRP00000018535 | ENSPTRP00000063078 | HPN isoform 1; Belongs to the peptidase S1 family. | Guanine nucleotide-binding protein G(s) subunit alpha. | 0.477 |
| HPN | MET | ENSPTRP00000018535 | ENSPTRP00000083162 | HPN isoform 1; Belongs to the peptidase S1 family. | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] | 0.641 |
| HPN | MST1 | ENSPTRP00000018535 | ENSPTRP00000051376 | HPN isoform 1; Belongs to the peptidase S1 family. | Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. | 0.713 |
| HPN | MST1R | ENSPTRP00000018535 | ENSPTRP00000025788 | HPN isoform 1; Belongs to the peptidase S1 family. | Macrophage stimulating 1 receptor. | 0.618 |
| HPN | SPINT1 | ENSPTRP00000018535 | ENSPTRP00000011835 | HPN isoform 1; Belongs to the peptidase S1 family. | SPINT1 isoform 2. | 0.727 |
| HPN | SPINT2 | ENSPTRP00000018535 | ENSPTRP00000065532 | HPN isoform 1; Belongs to the peptidase S1 family. | T0106202 isoform 2. | 0.619 |