STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HSPB6Heat shock protein, alpha-crystallin-related, B6; Belongs to the small heat shock protein (HSP20) family. (160 aa)    
Predicted Functional Partners:
TBC1D21
TBC1 domain family member 21.
      
 0.912
FN3K
Fructosamine 3 kinase; Belongs to the fructosamine kinase family.
      
 0.912
CIZ1
CIZ1 isoform 4.
    
 
 0.889
CIZ1-2
CDKN1A interacting zinc finger protein 1.
    
 
 0.889
GPSM2
G-protein-signaling modulator 2.
      
 0.885
SFN
SFN isoform 1; Belongs to the 14-3-3 family.
   
 
 0.837
BAG3
BCL2-associated athanogene 3.
   
 
 0.818
HSPA4
Heat shock protein family A (Hsp70) member 4.
   
 0.721
HSP90AB1
HSP90AB1 isoform 1.
   
 0.689
HSP90AA1
Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...]
   
 0.689
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.