HCST protein (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EMB	HCST	ENSPTRP00000028880	ENSPTRP00000018631	EMB isoform 2.	Hematopoietic cell signal transducer.	0.994
GRB2	HCST	ENSPTRP00000016382	ENSPTRP00000018631	Growth factor receptor-bound protein 2.	Hematopoietic cell signal transducer.	0.928
GRB2	KLRK1	ENSPTRP00000016382	ENSPTRP00000007992	Growth factor receptor-bound protein 2.	NKG2-D type II integral membrane protein; Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress- inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-exp [...]	0.459
GRB2	PIK3CA	ENSPTRP00000016382	ENSPTRP00000084763	Growth factor receptor-bound protein 2.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.958
GRB2	PIK3CB	ENSPTRP00000016382	ENSPTRP00000026618	Growth factor receptor-bound protein 2.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.902
GRB2	PIK3CD	ENSPTRP00000016382	ENSPTRP00000000229	Growth factor receptor-bound protein 2.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.859
GRB2	PIK3R1	ENSPTRP00000016382	ENSPTRP00000076964	Growth factor receptor-bound protein 2.	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha).	0.974
GRB2	PLCG1	ENSPTRP00000016382	ENSPTRP00000023178	Growth factor receptor-bound protein 2.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.977
GRB2	PLCG2	ENSPTRP00000016382	ENSPTRP00000076517	Growth factor receptor-bound protein 2.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.869
GRB2	TYROBP	ENSPTRP00000016382	ENSPTRP00000018632	Growth factor receptor-bound protein 2.	TYRO protein tyrosine kinase-binding protein; Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (By similarity). TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation (By similarity). Also has an inhibitory role in some cells (By similarity). Non-covalently associates with activating receptors [...]	0.491
HCST	EMB	ENSPTRP00000018631	ENSPTRP00000028880	Hematopoietic cell signal transducer.	EMB isoform 2.	0.994
HCST	GRB2	ENSPTRP00000018631	ENSPTRP00000016382	Hematopoietic cell signal transducer.	Growth factor receptor-bound protein 2.	0.928
HCST	KLRK1	ENSPTRP00000018631	ENSPTRP00000007992	Hematopoietic cell signal transducer.	NKG2-D type II integral membrane protein; Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress- inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-exp [...]	0.999
HCST	PIK3CA	ENSPTRP00000018631	ENSPTRP00000084763	Hematopoietic cell signal transducer.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.933
HCST	PIK3CB	ENSPTRP00000018631	ENSPTRP00000026618	Hematopoietic cell signal transducer.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.937
HCST	PIK3CD	ENSPTRP00000018631	ENSPTRP00000000229	Hematopoietic cell signal transducer.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.937
HCST	PIK3R1	ENSPTRP00000018631	ENSPTRP00000076964	Hematopoietic cell signal transducer.	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha).	0.909
HCST	PLCG1	ENSPTRP00000018631	ENSPTRP00000023178	Hematopoietic cell signal transducer.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.907
HCST	PLCG2	ENSPTRP00000018631	ENSPTRP00000076517	Hematopoietic cell signal transducer.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.914
HCST	TYROBP	ENSPTRP00000018631	ENSPTRP00000018632	Hematopoietic cell signal transducer.	TYRO protein tyrosine kinase-binding protein; Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (By similarity). TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation (By similarity). Also has an inhibitory role in some cells (By similarity). Non-covalently associates with activating receptors [...]	0.955