STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KLK2KLK2 isoform 5; Belongs to the peptidase S1 family. (261 aa)    
Predicted Functional Partners:
KLK3
Kallikrein related peptidase 3; Belongs to the peptidase S1 family.
  
 
0.941
KLK1
KLK1 isoform 3; Belongs to the peptidase S1 family.
  
  
0.903
SERPINA4
Serpin family A member 4; Belongs to the serpin family.
    
 0.902
AR
Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.
    
 0.845
SEMG2
Semenogelin-2; Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa.
    
 
 0.772
TGM4
Prostate-specific transglutaminase 4.
     
 0.728
ACP3
ACPP isoform 4; Belongs to the histidine acid phosphatase family.
    
 
 0.725
KNG1
KNG1 isoform 2.
   
 0.714
SERPINA5
Serpin family A member 5; Belongs to the serpin family.
    
 0.701
MSMB
Beta-microseminoprotein.
    
 
 0.691
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.