NCR1 protein (Pan troglodytes) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Cooccurrence

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[Homology]

Score

NCR1

NCR1 isoform 1. (303 aa)

Predicted Functional Partners:

CD247

0.976

FCER1G

0.968

NCR2

0.875

NCR2-2

0.875

KLRK1

0.772

TYROBP

0.735

RPS9

0.732

RPS9-2

0.732

CD244

0.731

OR10R2

0.724

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD244	CD247	ENSPTRP00000045917	ENSPTRP00000044167	CD244 isoform 1.	CD247 isoform 2.	0.424
CD244	KLRK1	ENSPTRP00000045917	ENSPTRP00000007992	CD244 isoform 1.	NKG2-D type II integral membrane protein; Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress- inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-exp [...]	0.666
CD244	NCR1	ENSPTRP00000045917	ENSPTRP00000019735	CD244 isoform 1.	NCR1 isoform 1.	0.731
CD247	CD244	ENSPTRP00000044167	ENSPTRP00000045917	CD247 isoform 2.	CD244 isoform 1.	0.424
CD247	FCER1G	ENSPTRP00000044167	ENSPTRP00000051638	CD247 isoform 2.	Fc fragment of IgE receptor Ig.	0.794
CD247	KLRK1	ENSPTRP00000044167	ENSPTRP00000007992	CD247 isoform 2.	NKG2-D type II integral membrane protein; Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress- inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-exp [...]	0.715
CD247	NCR1	ENSPTRP00000044167	ENSPTRP00000019735	CD247 isoform 2.	NCR1 isoform 1.	0.976
CD247	NCR2	ENSPTRP00000044167	ENSPTRP00000050164	CD247 isoform 2.	Natural cytotoxicity triggering receptor 2.	0.646
CD247	NCR2-2	ENSPTRP00000044167	ENSPTRP00000061795	CD247 isoform 2.	Natural cytotoxicity triggering receptor 2.	0.646
CD247	TYROBP	ENSPTRP00000044167	ENSPTRP00000018632	CD247 isoform 2.	TYRO protein tyrosine kinase-binding protein; Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (By similarity). TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation (By similarity). Also has an inhibitory role in some cells (By similarity). Non-covalently associates with activating receptors [...]	0.770
FCER1G	CD247	ENSPTRP00000051638	ENSPTRP00000044167	Fc fragment of IgE receptor Ig.	CD247 isoform 2.	0.794
FCER1G	KLRK1	ENSPTRP00000051638	ENSPTRP00000007992	Fc fragment of IgE receptor Ig.	NKG2-D type II integral membrane protein; Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress- inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-exp [...]	0.650
FCER1G	NCR1	ENSPTRP00000051638	ENSPTRP00000019735	Fc fragment of IgE receptor Ig.	NCR1 isoform 1.	0.968
FCER1G	NCR2	ENSPTRP00000051638	ENSPTRP00000050164	Fc fragment of IgE receptor Ig.	Natural cytotoxicity triggering receptor 2.	0.578
FCER1G	NCR2-2	ENSPTRP00000051638	ENSPTRP00000061795	Fc fragment of IgE receptor Ig.	Natural cytotoxicity triggering receptor 2.	0.578
FCER1G	TYROBP	ENSPTRP00000051638	ENSPTRP00000018632	Fc fragment of IgE receptor Ig.	TYRO protein tyrosine kinase-binding protein; Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (By similarity). TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation (By similarity). Also has an inhibitory role in some cells (By similarity). Non-covalently associates with activating receptors [...]	0.998
KLRK1	CD244	ENSPTRP00000007992	ENSPTRP00000045917	NKG2-D type II integral membrane protein; Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress- inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-exp [...]	CD244 isoform 1.	0.666
KLRK1	CD247	ENSPTRP00000007992	ENSPTRP00000044167	NKG2-D type II integral membrane protein; Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress- inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-exp [...]	CD247 isoform 2.	0.715
KLRK1	FCER1G	ENSPTRP00000007992	ENSPTRP00000051638	NKG2-D type II integral membrane protein; Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress- inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-exp [...]	Fc fragment of IgE receptor Ig.	0.650
KLRK1	NCR1	ENSPTRP00000007992	ENSPTRP00000019735	NKG2-D type II integral membrane protein; Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress- inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-exp [...]	NCR1 isoform 1.	0.772