STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RNF144ARBR-type E3 ubiquitin transferase. (292 aa)    
Predicted Functional Partners:
PRKDC
Protein kinase, DNA-activated, catalytic polypeptide; Belongs to the PI3/PI4-kinase family.
    
 0.950
UBC
Polyubiquitin-C; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...]
    
 0.606
RPS27A
RPS27A isoform 1.
    
 0.594
ENSPTRP00000060412
annotation not available
    
 0.594
KXD1
UBA52 isoform 10.
    
  0.527
ENSPTRP00000067263
Ubiquitin-large subunit ribosomal protein L40e.
    
  0.527
ENSPTRP00000071568
annotation not available
    
  0.527
TRIP12
Thyroid hormone receptor interactor 12.
   
 
 0.523
BIRC6
BIRC6 isoform 5.
    
 0.498
RNF216
Ring finger protein 216.
    
0.486
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.