STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KIDINS220Kinase D interacting substrate 220. (1771 aa)    
Predicted Functional Partners:
CRK
V-crk sarcoma virus CT10 oncogene homolog (Avian).
    
 0.990
NTRK1
Tyrosine-protein kinase receptor.
    
 0.977
CRKL
V-crk sarcoma virus CT10 oncogene homolog (Avian)-like.
    
 0.954
XPR1
Xenotropic and polytropic retrovirus receptor 1.
   
 
 0.763
MAGI2
Membrane associated guanylate kinase, WW and PDZ domain containing 2.
    
   0.697
NTRK2
Tyrosine-protein kinase receptor.
    
 0.656
ENSPTRP00000089450
annotation not available
    
 0.560
PRKD3
Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
    
 
 0.553
NGF
Beta-nerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (By similarity). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone colla [...]
     
 0.552
RND1
RND1 isoform 1.
   
 0.547
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.