STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
OTX1Orthodenticle homeobox 1. (354 aa)    
Predicted Functional Partners:
WDR70
WDR70 isoform 2.
      
 0.881
GFRA2
GDNF family receptor alpha-2; Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.
      
 0.700
NKX2-8
NKX2-8 isoform 1.
   
  
 0.670
PAX2
PAX2 isoform 1.
      
 0.585
NOTCH3
NOTCH3 isoform 1.
   
 
 0.486
FOXG1
FOXG1 isoform 8.
   
  
 0.480
NEUROG1
NEUROG1 isoform 1.
   
  
 0.476
TBR1
T-box brain transcription factor 1.
   
 
 0.476
EBF1
EBF transcription factor 1.
   
  
 0.475
DACH1
DACH1 isoform 4.
      
 0.474
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.