close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING newly available directed regulatory networks a new typed view showing functional, physical, and regulatory edges in one network new clustering options and cluster-based layouts … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
REG3ARegenerating family member 3 alpha. (175 aa)    
Predicted Functional Partners:
REG3G
Regenerating islet-derived protein 3-gamma.
  
 
 
0.898
DEFA5
Defensin-5; Has antimicrobial activity against Gram-negative and Gram- positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing (By similarity); Belongs to the alpha-defensin family.
   
  
 0.877
REG1B
Regenerating family member 1 beta.
  
  
0.869
DUOXA1
Dual oxidase maturation factor 1.
      
 0.796
DEFA6
Defensin-6; Has very low antimicrobial activity against Gram-negative and Gram-positive bacteria; Belongs to the alpha-defensin family.
   
 
 0.795
DUOXA2
Dual oxidase maturation factor 2.
      
 0.763
DUOX2
DUOX2 isoform 1.
   
 
 0.739
MUC1
Mucin 1, cell surface associated.
    
 0.542
ENSPTRP00000071463
LOW QUALITY PROTEIN: chondroitin sulfate proteoglycan 4.
     
 0.514
EXTL3
Exostosin like glycosyltransferase 3; Belongs to the glycosyltransferase 47 family.
      
 0.495
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: low (20%) [HD]