ZAP70 protein (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD247	CD3E	ENSPTRP00000044167	ENSPTRP00000007441	CD247 isoform 2.	CD3E isoform 2.	0.999
CD247	CD3G	ENSPTRP00000044167	ENSPTRP00000007443	CD247 isoform 2.	CD3G isoform 1.	0.999
CD247	CD4	ENSPTRP00000044167	ENSPTRP00000054833	CD247 isoform 2.	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	0.712
CD247	FCER1G	ENSPTRP00000044167	ENSPTRP00000051638	CD247 isoform 2.	Fc fragment of IgE receptor Ig.	0.556
CD247	LAT	ENSPTRP00000044167	ENSPTRP00000056922	CD247 isoform 2.	Linker for activation of T cells.	0.760
CD247	LCK	ENSPTRP00000044167	ENSPTRP00000000842	CD247 isoform 2.	Tyrosine-protein kinase.	0.977
CD247	LCP2	ENSPTRP00000044167	ENSPTRP00000029923	CD247 isoform 2.	Lymphocyte cytosolic protein 2.	0.817
CD247	SHC1	ENSPTRP00000044167	ENSPTRP00000051735	CD247 isoform 2.	SHC (Src homology 2 domain containing) transforming protein 1.	0.798
CD247	VAV1	ENSPTRP00000044167	ENSPTRP00000017657	CD247 isoform 2.	Vav guanine nucleotide exchange factor 1.	0.609
CD247	ZAP70	ENSPTRP00000044167	ENSPTRP00000021008	CD247 isoform 2.	Tyrosine-protein kinase.	0.999
CD3E	CD247	ENSPTRP00000007441	ENSPTRP00000044167	CD3E isoform 2.	CD247 isoform 2.	0.999
CD3E	CD3G	ENSPTRP00000007441	ENSPTRP00000007443	CD3E isoform 2.	CD3G isoform 1.	0.999
CD3E	CD4	ENSPTRP00000007441	ENSPTRP00000054833	CD3E isoform 2.	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	0.882
CD3E	LAT	ENSPTRP00000007441	ENSPTRP00000056922	CD3E isoform 2.	Linker for activation of T cells.	0.997
CD3E	LCK	ENSPTRP00000007441	ENSPTRP00000000842	CD3E isoform 2.	Tyrosine-protein kinase.	0.921
CD3E	LCP2	ENSPTRP00000007441	ENSPTRP00000029923	CD3E isoform 2.	Lymphocyte cytosolic protein 2.	0.625
CD3E	ZAP70	ENSPTRP00000007441	ENSPTRP00000021008	CD3E isoform 2.	Tyrosine-protein kinase.	0.998
CD3G	CD247	ENSPTRP00000007443	ENSPTRP00000044167	CD3G isoform 1.	CD247 isoform 2.	0.999
CD3G	CD3E	ENSPTRP00000007443	ENSPTRP00000007441	CD3G isoform 1.	CD3E isoform 2.	0.999
CD3G	CD4	ENSPTRP00000007443	ENSPTRP00000054833	CD3G isoform 1.	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	0.645