IL1R1 protein (Pan troglodytes) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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Assay-based Predictions

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co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IL1A	IL1B	ENSPTRP00000021189	ENSPTRP00000021191	Interleukin-1; Belongs to the IL-1 family.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.999
IL1A	IL1R1	ENSPTRP00000021189	ENSPTRP00000075043	Interleukin-1; Belongs to the IL-1 family.	Interleukin 1 receptor, type I.	0.997
IL1A	IL1R2	ENSPTRP00000021189	ENSPTRP00000021065	Interleukin-1; Belongs to the IL-1 family.	Interleukin 1 receptor type 2.	0.994
IL1A	IL1RAP	ENSPTRP00000021189	ENSPTRP00000083273	Interleukin-1; Belongs to the IL-1 family.	Interleukin 1 receptor accessory protein.	0.974
IL1A	IL1RN	ENSPTRP00000021189	ENSPTRP00000079895	Interleukin-1; Belongs to the IL-1 family.	Interleukin-1.	0.719
IL1A	IRAK1	ENSPTRP00000021189	ENSPTRP00000068595	Interleukin-1; Belongs to the IL-1 family.	Interleukin 1 receptor associated kinase 1.	0.683
IL1A	IRAK1-2	ENSPTRP00000021189	ENSPTRP00000038647	Interleukin-1; Belongs to the IL-1 family.	Interleukin-1 receptor-associated kinase 1.	0.683
IL1A	IRAK4	ENSPTRP00000021189	ENSPTRP00000008285	Interleukin-1; Belongs to the IL-1 family.	Interleukin-1 receptor-associated kinase 4.	0.703
IL1A	MYD88	ENSPTRP00000021189	ENSPTRP00000061524	Interleukin-1; Belongs to the IL-1 family.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...]	0.765
IL1A	TRAF6	ENSPTRP00000021189	ENSPTRP00000006096	Interleukin-1; Belongs to the IL-1 family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.733
IL1B	IL1A	ENSPTRP00000021191	ENSPTRP00000021189	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Interleukin-1; Belongs to the IL-1 family.	0.999
IL1B	IL1R1	ENSPTRP00000021191	ENSPTRP00000075043	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Interleukin 1 receptor, type I.	0.997
IL1B	IL1R2	ENSPTRP00000021191	ENSPTRP00000021065	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Interleukin 1 receptor type 2.	0.996
IL1B	IL1RAP	ENSPTRP00000021191	ENSPTRP00000083273	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Interleukin 1 receptor accessory protein.	0.994
IL1B	IL1RN	ENSPTRP00000021191	ENSPTRP00000079895	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Interleukin-1.	0.668
IL1B	IRAK1	ENSPTRP00000021191	ENSPTRP00000068595	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Interleukin 1 receptor associated kinase 1.	0.742
IL1B	IRAK1-2	ENSPTRP00000021191	ENSPTRP00000038647	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Interleukin-1 receptor-associated kinase 1.	0.742
IL1B	IRAK4	ENSPTRP00000021191	ENSPTRP00000008285	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Interleukin-1 receptor-associated kinase 4.	0.763
IL1B	MYD88	ENSPTRP00000021191	ENSPTRP00000061524	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...]	0.842
IL1B	TRAF6	ENSPTRP00000021191	ENSPTRP00000006096	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.781