| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CAPN1 | CAPN2 | ENSPTRP00000067819 | ENSPTRP00000091012 | Calpain 1, (Mu/I) large subunit; Belongs to the peptidase C2 family. | Calpain 2, (M/II) large subunit; Belongs to the peptidase C2 family. | 0.979 |
| CAPN1 | IL1A | ENSPTRP00000067819 | ENSPTRP00000021189 | Calpain 1, (Mu/I) large subunit; Belongs to the peptidase C2 family. | Interleukin-1; Belongs to the IL-1 family. | 0.904 |
| CAPN2 | CAPN1 | ENSPTRP00000091012 | ENSPTRP00000067819 | Calpain 2, (M/II) large subunit; Belongs to the peptidase C2 family. | Calpain 1, (Mu/I) large subunit; Belongs to the peptidase C2 family. | 0.979 |
| CAPN2 | IL1A | ENSPTRP00000091012 | ENSPTRP00000021189 | Calpain 2, (M/II) large subunit; Belongs to the peptidase C2 family. | Interleukin-1; Belongs to the IL-1 family. | 0.903 |
| CSF2 | IL1A | ENSPTRP00000029448 | ENSPTRP00000021189 | Colony stimulating factor 2. | Interleukin-1; Belongs to the IL-1 family. | 0.902 |
| CSF2 | IL1B | ENSPTRP00000029448 | ENSPTRP00000021191 | Colony stimulating factor 2. | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | 0.786 |
| CSF2 | IL2 | ENSPTRP00000029448 | ENSPTRP00000028193 | Colony stimulating factor 2. | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. | 0.932 |
| CSF2 | TNF | ENSPTRP00000029448 | ENSPTRP00000069905 | Colony stimulating factor 2. | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | 0.822 |
| IL1A | CAPN1 | ENSPTRP00000021189 | ENSPTRP00000067819 | Interleukin-1; Belongs to the IL-1 family. | Calpain 1, (Mu/I) large subunit; Belongs to the peptidase C2 family. | 0.904 |
| IL1A | CAPN2 | ENSPTRP00000021189 | ENSPTRP00000091012 | Interleukin-1; Belongs to the IL-1 family. | Calpain 2, (M/II) large subunit; Belongs to the peptidase C2 family. | 0.903 |
| IL1A | CSF2 | ENSPTRP00000021189 | ENSPTRP00000029448 | Interleukin-1; Belongs to the IL-1 family. | Colony stimulating factor 2. | 0.902 |
| IL1A | IL1B | ENSPTRP00000021189 | ENSPTRP00000021191 | Interleukin-1; Belongs to the IL-1 family. | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | 0.999 |
| IL1A | IL1R1 | ENSPTRP00000021189 | ENSPTRP00000075043 | Interleukin-1; Belongs to the IL-1 family. | Interleukin 1 receptor, type I. | 0.997 |
| IL1A | IL1R2 | ENSPTRP00000021189 | ENSPTRP00000021065 | Interleukin-1; Belongs to the IL-1 family. | Interleukin 1 receptor type 2. | 0.994 |
| IL1A | IL1RAP | ENSPTRP00000021189 | ENSPTRP00000083273 | Interleukin-1; Belongs to the IL-1 family. | Interleukin 1 receptor accessory protein. | 0.974 |
| IL1A | IL1RL2 | ENSPTRP00000021189 | ENSPTRP00000021069 | Interleukin-1; Belongs to the IL-1 family. | IL1RL2 isoform 1. | 0.911 |
| IL1A | IL2 | ENSPTRP00000021189 | ENSPTRP00000028193 | Interleukin-1; Belongs to the IL-1 family. | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. | 0.829 |
| IL1A | TNF | ENSPTRP00000021189 | ENSPTRP00000069905 | Interleukin-1; Belongs to the IL-1 family. | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | 0.950 |
| IL1B | CSF2 | ENSPTRP00000021191 | ENSPTRP00000029448 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | Colony stimulating factor 2. | 0.786 |
| IL1B | IL1A | ENSPTRP00000021191 | ENSPTRP00000021189 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | Interleukin-1; Belongs to the IL-1 family. | 0.999 |
