| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CASP1 | IL1A | ENSPTRP00000078835 | ENSPTRP00000021189 | CASP1 isoform 4; Belongs to the peptidase C14A family. | Interleukin-1; Belongs to the IL-1 family. | 0.736 |
| CASP1 | IL1B | ENSPTRP00000078835 | ENSPTRP00000021191 | CASP1 isoform 4; Belongs to the peptidase C14A family. | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | 0.997 |
| CASP1 | IL1R1 | ENSPTRP00000078835 | ENSPTRP00000075043 | CASP1 isoform 4; Belongs to the peptidase C14A family. | Interleukin 1 receptor, type I. | 0.640 |
| CASP1 | NFKB1 | ENSPTRP00000078835 | ENSPTRP00000028033 | CASP1 isoform 4; Belongs to the peptidase C14A family. | Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. | 0.601 |
| CASP1 | NLRP3 | ENSPTRP00000078835 | ENSPTRP00000003728 | CASP1 isoform 4; Belongs to the peptidase C14A family. | NLRP3 isoform 2. | 0.946 |
| CASP1 | PYCARD | ENSPTRP00000078835 | ENSPTRP00000013732 | CASP1 isoform 4; Belongs to the peptidase C14A family. | PYD and CARD domain containing. | 0.999 |
| CASP1 | TNF | ENSPTRP00000078835 | ENSPTRP00000069905 | CASP1 isoform 4; Belongs to the peptidase C14A family. | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | 0.773 |
| IL1A | CASP1 | ENSPTRP00000021189 | ENSPTRP00000078835 | Interleukin-1; Belongs to the IL-1 family. | CASP1 isoform 4; Belongs to the peptidase C14A family. | 0.736 |
| IL1A | IL1B | ENSPTRP00000021189 | ENSPTRP00000021191 | Interleukin-1; Belongs to the IL-1 family. | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | 0.999 |
| IL1A | IL1R1 | ENSPTRP00000021189 | ENSPTRP00000075043 | Interleukin-1; Belongs to the IL-1 family. | Interleukin 1 receptor, type I. | 0.997 |
| IL1A | IL1R2 | ENSPTRP00000021189 | ENSPTRP00000021065 | Interleukin-1; Belongs to the IL-1 family. | Interleukin 1 receptor type 2. | 0.994 |
| IL1A | IL1RAP | ENSPTRP00000021189 | ENSPTRP00000083273 | Interleukin-1; Belongs to the IL-1 family. | Interleukin 1 receptor accessory protein. | 0.974 |
| IL1A | NFKB1 | ENSPTRP00000021189 | ENSPTRP00000028033 | Interleukin-1; Belongs to the IL-1 family. | Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. | 0.769 |
| IL1A | NLRP3 | ENSPTRP00000021189 | ENSPTRP00000003728 | Interleukin-1; Belongs to the IL-1 family. | NLRP3 isoform 2. | 0.562 |
| IL1A | PYCARD | ENSPTRP00000021189 | ENSPTRP00000013732 | Interleukin-1; Belongs to the IL-1 family. | PYD and CARD domain containing. | 0.441 |
| IL1A | RELA | ENSPTRP00000021189 | ENSPTRP00000054405 | Interleukin-1; Belongs to the IL-1 family. | V-rel reticuloendotheliosis viral oncogene homolog A (Avian). | 0.642 |
| IL1A | TNF | ENSPTRP00000021189 | ENSPTRP00000069905 | Interleukin-1; Belongs to the IL-1 family. | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | 0.950 |
| IL1B | CASP1 | ENSPTRP00000021191 | ENSPTRP00000078835 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | CASP1 isoform 4; Belongs to the peptidase C14A family. | 0.997 |
| IL1B | IL1A | ENSPTRP00000021191 | ENSPTRP00000021189 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | Interleukin-1; Belongs to the IL-1 family. | 0.999 |
| IL1B | IL1R1 | ENSPTRP00000021191 | ENSPTRP00000075043 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | Interleukin 1 receptor, type I. | 0.997 |
