| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACKR3 | CXCL12 | ENSPTRP00000022362 | ENSPTRP00000067989 | Chemokine (C-X-C motif) receptor 7; Belongs to the G-protein coupled receptor 1 family. | C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. | 0.997 |
| ACKR3 | CXCR4 | ENSPTRP00000022362 | ENSPTRP00000074646 | Chemokine (C-X-C motif) receptor 7; Belongs to the G-protein coupled receptor 1 family. | C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] | 0.994 |
| CD4 | CXCL12 | ENSPTRP00000054833 | ENSPTRP00000067989 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. | 0.804 |
| CD4 | CXCR4 | ENSPTRP00000054833 | ENSPTRP00000074646 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] | 0.959 |
| CXCL12 | ACKR3 | ENSPTRP00000067989 | ENSPTRP00000022362 | C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. | Chemokine (C-X-C motif) receptor 7; Belongs to the G-protein coupled receptor 1 family. | 0.997 |
| CXCL12 | CD4 | ENSPTRP00000067989 | ENSPTRP00000054833 | C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | 0.804 |
| CXCL12 | CXCR4 | ENSPTRP00000067989 | ENSPTRP00000074646 | C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. | C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] | 0.999 |
| CXCL12 | GNAI1 | ENSPTRP00000067989 | ENSPTRP00000071974 | C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. | Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1. | 0.604 |
| CXCL12 | GNAI2 | ENSPTRP00000067989 | ENSPTRP00000025802 | C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. | Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2. | 0.588 |
| CXCL12 | GNAI3 | ENSPTRP00000067989 | ENSPTRP00000001821 | C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. | Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3. | 0.567 |
| CXCL12 | GNB1 | ENSPTRP00000067989 | ENSPTRP00000067330 | C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. | Guanine nucleotide binding protein (G protein), beta polypeptide 1. | 0.597 |
| CXCL12 | GNB2 | ENSPTRP00000067989 | ENSPTRP00000085287 | C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. | Guanine nucleotide binding protein (G protein), beta polypeptide 2. | 0.523 |
| CXCL12 | GNB4 | ENSPTRP00000067989 | ENSPTRP00000026924 | C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. | Guanine nucleotide binding protein (G protein), beta polypeptide 4. | 0.529 |
| CXCL12 | GNG2 | ENSPTRP00000067989 | ENSPTRP00000065345 | C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.576 |
| CXCR4 | ACKR3 | ENSPTRP00000074646 | ENSPTRP00000022362 | C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] | Chemokine (C-X-C motif) receptor 7; Belongs to the G-protein coupled receptor 1 family. | 0.994 |
| CXCR4 | CD4 | ENSPTRP00000074646 | ENSPTRP00000054833 | C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | 0.959 |
| CXCR4 | CXCL12 | ENSPTRP00000074646 | ENSPTRP00000067989 | C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] | C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. | 0.999 |
| CXCR4 | GNAI1 | ENSPTRP00000074646 | ENSPTRP00000071974 | C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] | Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1. | 0.972 |
| CXCR4 | GNAI2 | ENSPTRP00000074646 | ENSPTRP00000025802 | C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] | Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2. | 0.950 |
| CXCR4 | GNAI3 | ENSPTRP00000074646 | ENSPTRP00000001821 | C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] | Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3. | 0.956 |
