STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
IFIH1IFIH1 isoform 1. (1025 aa)    
Predicted Functional Partners:
MAVS
Mitochondrial antiviral signaling protein.
    
 0.999
TKFC
Dihydroxyacetone kinase 2 homolog.
    
 0.993
DHX58
DEXH (Asp-Glu-X-His) box polypeptide 58.
   
0.989
RNF125
Ring finger protein 125.
    
 0.970
IFIT1
Interferon-induced protein with tetratricopeptide repeats 1.
   
 0.954
OASL
OASL isoform 1.
   
 0.951
IFIT2
Interferon-induced protein with tetratricopeptide repeats 2.
   
 0.948
DDX60
DDX60 isoform 1.
   
 
 0.948
TRIM65
Tripartite motif containing 65.
   
 0.945
IFIT3
Interferon-induced protein with tetratricopeptide repeats 3; IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B [...]
   
 0.937
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.