| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CALHM1 | PDE1A | ENSPTRP00000005130 | ENSPTRP00000082071 | Calcium homeostasis modulator 1. | Phosphodiesterase. | 0.837 |
| CALHM1 | SCN2A | ENSPTRP00000005130 | ENSPTRP00000074490 | Calcium homeostasis modulator 1. | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | 0.907 |
| CALHM1 | SCN3A | ENSPTRP00000005130 | ENSPTRP00000054785 | Calcium homeostasis modulator 1. | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | 0.931 |
| CALHM1 | SCN9A | ENSPTRP00000005130 | ENSPTRP00000021521 | Calcium homeostasis modulator 1. | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | 0.929 |
| CSMD2 | PDE1A | ENSPTRP00000052558 | ENSPTRP00000082071 | CUB and Sushi multiple domains 2. | Phosphodiesterase. | 0.850 |
| CSMD2 | SCN9A | ENSPTRP00000052558 | ENSPTRP00000021521 | CUB and Sushi multiple domains 2. | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | 0.857 |
| PDE1A | CALHM1 | ENSPTRP00000082071 | ENSPTRP00000005130 | Phosphodiesterase. | Calcium homeostasis modulator 1. | 0.837 |
| PDE1A | CSMD2 | ENSPTRP00000082071 | ENSPTRP00000052558 | Phosphodiesterase. | CUB and Sushi multiple domains 2. | 0.850 |
| PDE1A | SCN9A | ENSPTRP00000082071 | ENSPTRP00000021521 | Phosphodiesterase. | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | 0.822 |
| SCN1B | SCN2A | ENSPTRP00000089848 | ENSPTRP00000074490 | Sodium channel subunit beta-1; Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A. | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | 0.948 |
| SCN1B | SCN2B | ENSPTRP00000089848 | ENSPTRP00000072074 | Sodium channel subunit beta-1; Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A. | Sodium voltage-gated channel beta subunit 2. | 0.987 |
| SCN1B | SCN3A | ENSPTRP00000089848 | ENSPTRP00000054785 | Sodium channel subunit beta-1; Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A. | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | 0.976 |
| SCN1B | SCN3B | ENSPTRP00000089848 | ENSPTRP00000007545 | Sodium channel subunit beta-1; Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A. | Sodium voltage-gated channel beta subunit 3. | 0.756 |
| SCN1B | SCN4B | ENSPTRP00000089848 | ENSPTRP00000091439 | Sodium channel subunit beta-1; Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A. | Sodium voltage-gated channel beta subunit 4. | 0.983 |
| SCN1B | SCN9A | ENSPTRP00000089848 | ENSPTRP00000021521 | Sodium channel subunit beta-1; Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A. | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | 0.993 |
| SCN2A | CALHM1 | ENSPTRP00000074490 | ENSPTRP00000005130 | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | Calcium homeostasis modulator 1. | 0.907 |
| SCN2A | SCN1B | ENSPTRP00000074490 | ENSPTRP00000089848 | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | Sodium channel subunit beta-1; Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A. | 0.948 |
| SCN2A | SCN2B | ENSPTRP00000074490 | ENSPTRP00000072074 | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | Sodium voltage-gated channel beta subunit 2. | 0.973 |
| SCN2A | SCN3A | ENSPTRP00000074490 | ENSPTRP00000054785 | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | 0.980 |
| SCN2A | SCN3B | ENSPTRP00000074490 | ENSPTRP00000007545 | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | Sodium voltage-gated channel beta subunit 3. | 0.889 |