STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LRP2LRP2 isoform 1. (4655 aa)    
Predicted Functional Partners:
APOE
Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]
    
 0.987
LRPAP1
Low density lipoprotein receptor-related protein associated protein 1.
    
 0.985
DAB2
Disabled homolog 2, mitogen-responsive phosphoprotein.
    
 0.982
SHH
Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.
     
 0.975
ANKRA2
Ankyrin repeat, family A (RFXANK-like), 2.
    
 0.971
LDLRAP1
Low density lipoprotein receptor adaptor protein 1.
    
 0.966
CUBN
CUBN isoform 1.
   
 0.958
TG
TG isoform 3.
     
 0.953
LRP1
LDL receptor related protein 1.
     
0.930
IHH
Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.
     
 0.922
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.