CHRNA1 protein (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHRNA1	CHRNA5	ENSPTRP00000021633	ENSPTRP00000012554	Cholinergic receptor, nicotinic, alpha 1 (Muscle).	Neuronal acetylcholine receptor subunit alpha-5; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.	0.788
CHRNA1	CHRNA6	ENSPTRP00000021633	ENSPTRP00000034613	Cholinergic receptor, nicotinic, alpha 1 (Muscle).	Neuronal acetylcholine receptor subunit alpha-6; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.	0.799
CHRNA1	CHRNA7	ENSPTRP00000021633	ENSPTRP00000011728	Cholinergic receptor, nicotinic, alpha 1 (Muscle).	CHRNA7 isoform 7.	0.805
CHRNA1	CHRNB1	ENSPTRP00000021633	ENSPTRP00000014815	Cholinergic receptor, nicotinic, alpha 1 (Muscle).	Cholinergic receptor, nicotinic, beta 1 (Muscle).	0.946
CHRNA1	CHRNB3	ENSPTRP00000021633	ENSPTRP00000054732	Cholinergic receptor, nicotinic, alpha 1 (Muscle).	Neuronal acetylcholine receptor subunit beta-3; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.	0.799
CHRNA1	CHRND	ENSPTRP00000021633	ENSPTRP00000022297	Cholinergic receptor, nicotinic, alpha 1 (Muscle).	Cholinergic receptor nicotinic delta subunit.	0.944
CHRNA1	CHRNE	ENSPTRP00000021633	ENSPTRP00000014702	Cholinergic receptor, nicotinic, alpha 1 (Muscle).	Cholinergic receptor nicotinic epsilon subunit.	0.929
CHRNA1	CHRNG	ENSPTRP00000021633	ENSPTRP00000046107	Cholinergic receptor, nicotinic, alpha 1 (Muscle).	Cholinergic receptor nicotinic gamma subunit.	0.926
CHRNA1	LYNX1	ENSPTRP00000021633	ENSPTRP00000035291	Cholinergic receptor, nicotinic, alpha 1 (Muscle).	Ly-6/neurotoxin-like protein 1; Acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs). The proposed role as modulator of nAChR activity seems to be dependent on the nAChR subtype and stoichiometry, and to involve an effect on nAChR trafficking and its cell surface expression, and on single channel properties of the nAChR inserted in the plasma membrane.Modulates functional properties of nicotinic acetylcholine receptors (nAChRs) to prevent excessive excitation, and hence neurodegeneration. Enhances desensitization by increasing both the rate and ex [...]	0.774
CHRNA1	SNX19	ENSPTRP00000021633	ENSPTRP00000007677	Cholinergic receptor, nicotinic, alpha 1 (Muscle).	Sorting nexin 19.	0.827
CHRNA5	CHRNA1	ENSPTRP00000012554	ENSPTRP00000021633	Neuronal acetylcholine receptor subunit alpha-5; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.	Cholinergic receptor, nicotinic, alpha 1 (Muscle).	0.788
CHRNA5	CHRNA6	ENSPTRP00000012554	ENSPTRP00000034613	Neuronal acetylcholine receptor subunit alpha-5; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.	Neuronal acetylcholine receptor subunit alpha-6; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.	0.977
CHRNA5	CHRNA7	ENSPTRP00000012554	ENSPTRP00000011728	Neuronal acetylcholine receptor subunit alpha-5; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.	CHRNA7 isoform 7.	0.972
CHRNA5	CHRNB1	ENSPTRP00000012554	ENSPTRP00000014815	Neuronal acetylcholine receptor subunit alpha-5; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.	Cholinergic receptor, nicotinic, beta 1 (Muscle).	0.977
CHRNA5	CHRNB3	ENSPTRP00000012554	ENSPTRP00000054732	Neuronal acetylcholine receptor subunit alpha-5; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.	Neuronal acetylcholine receptor subunit beta-3; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.	0.942
CHRNA5	CHRND	ENSPTRP00000012554	ENSPTRP00000022297	Neuronal acetylcholine receptor subunit alpha-5; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.	Cholinergic receptor nicotinic delta subunit.	0.959
CHRNA5	CHRNE	ENSPTRP00000012554	ENSPTRP00000014702	Neuronal acetylcholine receptor subunit alpha-5; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.	Cholinergic receptor nicotinic epsilon subunit.	0.977
CHRNA5	CHRNG	ENSPTRP00000012554	ENSPTRP00000046107	Neuronal acetylcholine receptor subunit alpha-5; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.	Cholinergic receptor nicotinic gamma subunit.	0.977
CHRNA5	LYNX1	ENSPTRP00000012554	ENSPTRP00000035291	Neuronal acetylcholine receptor subunit alpha-5; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.	Ly-6/neurotoxin-like protein 1; Acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs). The proposed role as modulator of nAChR activity seems to be dependent on the nAChR subtype and stoichiometry, and to involve an effect on nAChR trafficking and its cell surface expression, and on single channel properties of the nAChR inserted in the plasma membrane.Modulates functional properties of nicotinic acetylcholine receptors (nAChRs) to prevent excessive excitation, and hence neurodegeneration. Enhances desensitization by increasing both the rate and ex [...]	0.881
CHRNA6	CHRNA1	ENSPTRP00000034613	ENSPTRP00000021633	Neuronal acetylcholine receptor subunit alpha-6; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.	Cholinergic receptor, nicotinic, alpha 1 (Muscle).	0.799