| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ASS1 | CAD | ENSPTRP00000036742 | ENSPTRP00000086335 | Argininosuccinate synthetase 1. | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | 0.967 |
| ASS1 | CPS1 | ENSPTRP00000036742 | ENSPTRP00000087073 | Argininosuccinate synthetase 1. | Carbamoyl-phosphate synthase 1, mitochondrial. | 0.955 |
| ASS1 | ENSPTRP00000071015 | ENSPTRP00000036742 | ENSPTRP00000071015 | Argininosuccinate synthetase 1. | annotation not available | 0.901 |
| ASS1 | ENSPTRP00000087913 | ENSPTRP00000036742 | ENSPTRP00000087913 | Argininosuccinate synthetase 1. | annotation not available | 0.850 |
| ASS1 | OTC | ENSPTRP00000036742 | ENSPTRP00000037399 | Argininosuccinate synthetase 1. | Ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. | 0.984 |
| CAD | ASS1 | ENSPTRP00000086335 | ENSPTRP00000036742 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | Argininosuccinate synthetase 1. | 0.967 |
| CAD | CPS1 | ENSPTRP00000086335 | ENSPTRP00000087073 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | Carbamoyl-phosphate synthase 1, mitochondrial. | 0.902 |
| CAD | ENSPTRP00000071015 | ENSPTRP00000086335 | ENSPTRP00000071015 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | annotation not available | 0.967 |
| CAD | ENSPTRP00000087913 | ENSPTRP00000086335 | ENSPTRP00000087913 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | annotation not available | 0.858 |
| CAD | GLS | ENSPTRP00000086335 | ENSPTRP00000021790 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | GLS isoform 1. | 0.949 |
| CAD | GLS2 | ENSPTRP00000086335 | ENSPTRP00000008680 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | GLS2 isoform 4. | 0.920 |
| CAD | GLUD1 | ENSPTRP00000086335 | ENSPTRP00000004734 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | Glutamate dehydrogenase 2, mitochondrial; Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.437 |
| CAD | GLUL | ENSPTRP00000086335 | ENSPTRP00000002925 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | Glutamine synthetase. | 0.953 |
| CAD | OTC | ENSPTRP00000086335 | ENSPTRP00000037399 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | Ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. | 0.985 |
| CAD | SIRT5 | ENSPTRP00000086335 | ENSPTRP00000078138 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...] | 0.739 |
| CPS1 | ASS1 | ENSPTRP00000087073 | ENSPTRP00000036742 | Carbamoyl-phosphate synthase 1, mitochondrial. | Argininosuccinate synthetase 1. | 0.955 |
| CPS1 | CAD | ENSPTRP00000087073 | ENSPTRP00000086335 | Carbamoyl-phosphate synthase 1, mitochondrial. | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | 0.902 |
| CPS1 | ENSPTRP00000071015 | ENSPTRP00000087073 | ENSPTRP00000071015 | Carbamoyl-phosphate synthase 1, mitochondrial. | annotation not available | 0.951 |
| CPS1 | ENSPTRP00000087913 | ENSPTRP00000087073 | ENSPTRP00000087913 | Carbamoyl-phosphate synthase 1, mitochondrial. | annotation not available | 0.910 |
| CPS1 | GLS | ENSPTRP00000087073 | ENSPTRP00000021790 | Carbamoyl-phosphate synthase 1, mitochondrial. | GLS isoform 1. | 0.920 |
