close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ERBB4Receptor protein-tyrosine kinase. (1386 aa)    
Predicted Functional Partners:
NRG2
NRG2 isoform 3.
    
 0.999
NRG1
NRG1 isoform 3.
    
 0.997
ERBB2
Receptor protein-tyrosine kinase.
  
 
0.996
GRB2
Growth factor receptor-bound protein 2.
    
 0.995
SHC1
SHC (Src homology 2 domain containing) transforming protein 1.
    
 0.995
HBEGF
Heparin-binding EGF-like growth factor.
    
 0.994
EREG
EREG isoform 1.
    
 0.992
NRG4
NRG4 isoform 3.
   
 0.992
DLG4
Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.
    
 0.991
BTC
BTC isoform 1.
    
 0.991
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.