| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| COMT | CYP1A1 | ENSPTRP00000024231 | ENSPTRP00000058539 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. | Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. | 0.952 |
| COMT | CYP1B1 | ENSPTRP00000024231 | ENSPTRP00000020335 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. | Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. | 0.955 |
| COMT | UGT1A3 | ENSPTRP00000024231 | ENSPTRP00000082441 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. | UDP-glucuronosyltransferase 1-3 isoform X2. | 0.938 |
| CYP19A1 | CYP1A1 | ENSPTRP00000012092 | ENSPTRP00000058539 | Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. | Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. | 0.948 |
| CYP19A1 | CYP1A2 | ENSPTRP00000012092 | ENSPTRP00000070670 | Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. | Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. | 0.508 |
| CYP19A1 | CYP1B1 | ENSPTRP00000012092 | ENSPTRP00000020335 | Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. | Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. | 0.627 |
| CYP19A1 | CYP2D6 | ENSPTRP00000012092 | ENSPTRP00000042793 | Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. | Cytochrome P450 2D6; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids, steroids and retinoids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA). Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 20-hydroxyeicosatetraenoic acid ethanolamide (20-HETE-EA) and 8,9-, 11,12-, and 14,15-epoxyei [...] | 0.403 |
| CYP19A1 | CYP2E1 | ENSPTRP00000012092 | ENSPTRP00000005465 | Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. | Cytochrome P450 family 2 subfamily E member 1; Belongs to the cytochrome P450 family. | 0.440 |
| CYP19A1 | CYP3A4 | ENSPTRP00000012092 | ENSPTRP00000081767 | Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. | Cytochrome P450 family 3 subfamily A member 4. | 0.937 |
| CYP19A1 | CYP3A5 | ENSPTRP00000012092 | ENSPTRP00000033296 | Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. | CYP3A5 isoform 1. | 0.936 |
| CYP19A1 | SULT1E1 | ENSPTRP00000012092 | ENSPTRP00000027719 | Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. | Sulfotransferase; Belongs to the sulfotransferase 1 family. | 0.930 |
| CYP19A1 | UGT1A3 | ENSPTRP00000012092 | ENSPTRP00000082441 | Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. | UDP-glucuronosyltransferase 1-3 isoform X2. | 0.925 |
| CYP1A1 | COMT | ENSPTRP00000058539 | ENSPTRP00000024231 | Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. | 0.952 |
| CYP1A1 | CYP19A1 | ENSPTRP00000058539 | ENSPTRP00000012092 | Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. | Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. | 0.948 |
| CYP1A1 | CYP1A2 | ENSPTRP00000058539 | ENSPTRP00000070670 | Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. | Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. | 0.924 |
| CYP1A1 | CYP1B1 | ENSPTRP00000058539 | ENSPTRP00000020335 | Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. | Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. | 0.944 |
| CYP1A1 | CYP2D6 | ENSPTRP00000058539 | ENSPTRP00000042793 | Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. | Cytochrome P450 2D6; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids, steroids and retinoids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA). Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 20-hydroxyeicosatetraenoic acid ethanolamide (20-HETE-EA) and 8,9-, 11,12-, and 14,15-epoxyei [...] | 0.934 |
| CYP1A1 | CYP2E1 | ENSPTRP00000058539 | ENSPTRP00000005465 | Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. | Cytochrome P450 family 2 subfamily E member 1; Belongs to the cytochrome P450 family. | 0.940 |
| CYP1A1 | CYP3A4 | ENSPTRP00000058539 | ENSPTRP00000081767 | Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. | Cytochrome P450 family 3 subfamily A member 4. | 0.958 |
| CYP1A1 | CYP3A5 | ENSPTRP00000058539 | ENSPTRP00000033296 | Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. | CYP3A5 isoform 1. | 0.952 |
