| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCND1 | CDK4 | ENSPTRP00000086048 | ENSPTRP00000039845 | CCND1 isoform 1; Belongs to the cyclin family. | Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. | 0.999 |
| CCND1 | PCNA | ENSPTRP00000086048 | ENSPTRP00000022674 | CCND1 isoform 1; Belongs to the cyclin family. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.996 |
| CDK4 | CCND1 | ENSPTRP00000039845 | ENSPTRP00000086048 | Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. | CCND1 isoform 1; Belongs to the cyclin family. | 0.999 |
| CDK4 | LIG1 | ENSPTRP00000039845 | ENSPTRP00000019263 | Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. | DNA ligase. | 0.417 |
| CDK4 | PCNA | ENSPTRP00000039845 | ENSPTRP00000022674 | Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.992 |
| CDK4 | RFC4 | ENSPTRP00000039845 | ENSPTRP00000068354 | Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. | Replication factor C (Activator 1) 4, 37kDa. | 0.490 |
| CDK4 | SPIB | ENSPTRP00000039845 | ENSPTRP00000066005 | Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. | T0182711 isoform 1. | 0.532 |
| FEN1 | LIG1 | ENSPTRP00000006454 | ENSPTRP00000019263 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA ligase. | 0.983 |
| FEN1 | MSH6 | ENSPTRP00000006454 | ENSPTRP00000020434 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). | 0.909 |
| FEN1 | PCNA | ENSPTRP00000006454 | ENSPTRP00000022674 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.995 |
| FEN1 | RAD18 | ENSPTRP00000006454 | ENSPTRP00000025139 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | RAD18 isoform 2. | 0.415 |
| FEN1 | RFC3 | ENSPTRP00000006454 | ENSPTRP00000009832 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Replication factor C (Activator 1) 3, 38kDa. | 0.887 |
| FEN1 | RFC4 | ENSPTRP00000006454 | ENSPTRP00000068354 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Replication factor C (Activator 1) 4, 37kDa. | 0.898 |
| FEN1 | RFC5 | ENSPTRP00000006454 | ENSPTRP00000009355 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Replication factor C (Activator 1) 5, 36.5kDa. | 0.811 |
| FEN1 | SPIB | ENSPTRP00000006454 | ENSPTRP00000066005 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | T0182711 isoform 1. | 0.939 |
| LIG1 | CDK4 | ENSPTRP00000019263 | ENSPTRP00000039845 | DNA ligase. | Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. | 0.417 |
| LIG1 | FEN1 | ENSPTRP00000019263 | ENSPTRP00000006454 | DNA ligase. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.983 |
| LIG1 | MSH6 | ENSPTRP00000019263 | ENSPTRP00000020434 | DNA ligase. | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). | 0.718 |
| LIG1 | PCNA | ENSPTRP00000019263 | ENSPTRP00000022674 | DNA ligase. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.993 |
| LIG1 | RFC3 | ENSPTRP00000019263 | ENSPTRP00000009832 | DNA ligase. | Replication factor C (Activator 1) 3, 38kDa. | 0.919 |
