node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CPE | INS | ENSPTRP00000038931 | ENSPTRP00000077843 | Carboxypeptidase E; Sorting receptor that directs prohormones to the regulated secretory pathway. Acts also as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after initial endoprotease cleavage. | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.831 |
CPE | PCSK2 | ENSPTRP00000038931 | ENSPTRP00000022764 | Carboxypeptidase E; Sorting receptor that directs prohormones to the regulated secretory pathway. Acts also as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after initial endoprotease cleavage. | Proprotein convertase subtilisin/kexin type 2; Belongs to the peptidase S8 family. | 0.634 |
CPE | POMC | ENSPTRP00000038931 | ENSPTRP00000052139 | Carboxypeptidase E; Sorting receptor that directs prohormones to the regulated secretory pathway. Acts also as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after initial endoprotease cleavage. | Proopiomelanocortin. | 0.763 |
CPE | PTPRN2 | ENSPTRP00000038931 | ENSPTRP00000077891 | Carboxypeptidase E; Sorting receptor that directs prohormones to the regulated secretory pathway. Acts also as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after initial endoprotease cleavage. | PTPRN2 isoform 5. | 0.531 |
CPE | SCG5 | ENSPTRP00000038931 | ENSPTRP00000055998 | Carboxypeptidase E; Sorting receptor that directs prohormones to the regulated secretory pathway. Acts also as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after initial endoprotease cleavage. | Neuroendocrine protein 7B2; Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro (By similarity). | 0.434 |
DDX17 | PCSK2 | ENSPTRP00000062822 | ENSPTRP00000022764 | DEAD-box helicase 17; Belongs to the DEAD box helicase family. | Proprotein convertase subtilisin/kexin type 2; Belongs to the peptidase S8 family. | 0.531 |
GCG | INS | ENSPTRP00000049083 | ENSPTRP00000077843 | GCG isoform 1. | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.838 |
GCG | PCSK2 | ENSPTRP00000049083 | ENSPTRP00000022764 | GCG isoform 1. | Proprotein convertase subtilisin/kexin type 2; Belongs to the peptidase S8 family. | 0.593 |
GCG | POMC | ENSPTRP00000049083 | ENSPTRP00000052139 | GCG isoform 1. | Proopiomelanocortin. | 0.727 |
INS | CPE | ENSPTRP00000077843 | ENSPTRP00000038931 | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Carboxypeptidase E; Sorting receptor that directs prohormones to the regulated secretory pathway. Acts also as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after initial endoprotease cleavage. | 0.831 |
INS | GCG | ENSPTRP00000077843 | ENSPTRP00000049083 | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | GCG isoform 1. | 0.838 |
INS | PCSK2 | ENSPTRP00000077843 | ENSPTRP00000022764 | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Proprotein convertase subtilisin/kexin type 2; Belongs to the peptidase S8 family. | 0.743 |
INS | POMC | ENSPTRP00000077843 | ENSPTRP00000052139 | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Proopiomelanocortin. | 0.684 |
INS | PTPRN | ENSPTRP00000077843 | ENSPTRP00000077663 | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Protein tyrosine phosphatase, receptor type, N. | 0.633 |
PCSK2 | CPE | ENSPTRP00000022764 | ENSPTRP00000038931 | Proprotein convertase subtilisin/kexin type 2; Belongs to the peptidase S8 family. | Carboxypeptidase E; Sorting receptor that directs prohormones to the regulated secretory pathway. Acts also as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after initial endoprotease cleavage. | 0.634 |
PCSK2 | DDX17 | ENSPTRP00000022764 | ENSPTRP00000062822 | Proprotein convertase subtilisin/kexin type 2; Belongs to the peptidase S8 family. | DEAD-box helicase 17; Belongs to the DEAD box helicase family. | 0.531 |
PCSK2 | GCG | ENSPTRP00000022764 | ENSPTRP00000049083 | Proprotein convertase subtilisin/kexin type 2; Belongs to the peptidase S8 family. | GCG isoform 1. | 0.593 |
PCSK2 | INS | ENSPTRP00000022764 | ENSPTRP00000077843 | Proprotein convertase subtilisin/kexin type 2; Belongs to the peptidase S8 family. | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.743 |
PCSK2 | POMC | ENSPTRP00000022764 | ENSPTRP00000052139 | Proprotein convertase subtilisin/kexin type 2; Belongs to the peptidase S8 family. | Proopiomelanocortin. | 0.623 |
PCSK2 | PTPRN | ENSPTRP00000022764 | ENSPTRP00000077663 | Proprotein convertase subtilisin/kexin type 2; Belongs to the peptidase S8 family. | Protein tyrosine phosphatase, receptor type, N. | 0.545 |