THBD protein (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD46	CD47	ENSPTRP00000081199	ENSPTRP00000080534	CD46 isoform 5.	CD47 isoform 2.	0.552
CD46	CD55	ENSPTRP00000081199	ENSPTRP00000056033	CD46 isoform 5.	CD55 isoform 7.	0.517
CD46	TFPI	ENSPTRP00000081199	ENSPTRP00000021752	CD46 isoform 5.	Tissue factor pathway inhibitor.	0.405
CD46	THBD	ENSPTRP00000081199	ENSPTRP00000022833	CD46 isoform 5.	THBD isoform 1.	0.737
CD47	CD46	ENSPTRP00000080534	ENSPTRP00000081199	CD47 isoform 2.	CD46 isoform 5.	0.552
CD47	CD55	ENSPTRP00000080534	ENSPTRP00000056033	CD47 isoform 2.	CD55 isoform 7.	0.632
CD47	THBD	ENSPTRP00000080534	ENSPTRP00000022833	CD47 isoform 2.	THBD isoform 1.	0.761
CD55	CD46	ENSPTRP00000056033	ENSPTRP00000081199	CD55 isoform 7.	CD46 isoform 5.	0.517
CD55	CD47	ENSPTRP00000056033	ENSPTRP00000080534	CD55 isoform 7.	CD47 isoform 2.	0.632
CD55	TFPI	ENSPTRP00000056033	ENSPTRP00000021752	CD55 isoform 7.	Tissue factor pathway inhibitor.	0.524
CD55	TFPI2	ENSPTRP00000056033	ENSPTRP00000033200	CD55 isoform 7.	Tissue factor pathway inhibitor.	0.522
CD55	THBD	ENSPTRP00000056033	ENSPTRP00000022833	CD55 isoform 7.	THBD isoform 1.	0.786
F2	F3	ENSPTRP00000006168	ENSPTRP00000040007	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.	0.917
F2	PROC	ENSPTRP00000006168	ENSPTRP00000064418	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Protein C, inactivator of coagulation factors Va and VIIIa.	0.986
F2	PROCR	ENSPTRP00000006168	ENSPTRP00000052237	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Protein C receptor, endothelial.	0.910
F2	TFPI	ENSPTRP00000006168	ENSPTRP00000021752	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Tissue factor pathway inhibitor.	0.726
F2	TFPI2	ENSPTRP00000006168	ENSPTRP00000033200	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Tissue factor pathway inhibitor.	0.440
F2	THBD	ENSPTRP00000006168	ENSPTRP00000022833	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	THBD isoform 1.	0.986
F2	VWF	ENSPTRP00000006168	ENSPTRP00000007801	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Von Willebrand factor.	0.874
F3	F2	ENSPTRP00000040007	ENSPTRP00000006168	Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.917