STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ABCG1ABCG1 isoform 8. (807 aa)    
Predicted Functional Partners:
ABCG5
ATP binding cassette subfamily G member 5.
   
0.832
APOE
Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]
      
 0.773
NR1H3
Nuclear receptor subfamily 1 group H member 3.
   
 0.760
SREBF2
Sterol regulatory element binding transcription factor 2.
    
 
 0.745
NPC1
Niemann-Pick disease, type C1.
   
 
 0.716
NR1H2
Nuclear receptor subfamily 1, group H, member 2.
   
 0.695
XPR1
Xenotropic and polytropic retrovirus receptor 1.
   
  
 0.677
SCARB1
SCARB1 isoform 8; Belongs to the CD36 family.
   
  
 0.664
SREBF1
SREBF1 isoform 6.
    
 
 0.662
CYP7A1
Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.
   
 
 0.661
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.