XBP1 protein (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATF6	ATF6B	ENSPTRP00000002668	ENSPTRP00000057131	Activating transcription factor 6.	Activating transcription factor 6 beta.	0.951
ATF6	DDIT3	ENSPTRP00000002668	ENSPTRP00000043666	Activating transcription factor 6.	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	0.989
ATF6	EDEM1	ENSPTRP00000002668	ENSPTRP00000025126	Activating transcription factor 6.	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	0.688
ATF6	ERN1	ENSPTRP00000002668	ENSPTRP00000080224	Activating transcription factor 6.	Endoplasmic reticulum to nucleus signaling 1.	0.763
ATF6	HSPA5	ENSPTRP00000002668	ENSPTRP00000000984	Activating transcription factor 6.	Heat shock 70kDa protein 5 (Glucose-regulated protein, 78kDa); Belongs to the heat shock protein 70 family.	0.998
ATF6	TRAF2	ENSPTRP00000002668	ENSPTRP00000036949	Activating transcription factor 6.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.424
ATF6	XBP1	ENSPTRP00000002668	ENSPTRP00000065969	Activating transcription factor 6.	XBP1 isoform 4.	0.974
ATF6B	ATF6	ENSPTRP00000057131	ENSPTRP00000002668	Activating transcription factor 6 beta.	Activating transcription factor 6.	0.951
ATF6B	DDIT3	ENSPTRP00000057131	ENSPTRP00000043666	Activating transcription factor 6 beta.	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	0.959
ATF6B	EDEM1	ENSPTRP00000057131	ENSPTRP00000025126	Activating transcription factor 6 beta.	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	0.408
ATF6B	ERN1	ENSPTRP00000057131	ENSPTRP00000080224	Activating transcription factor 6 beta.	Endoplasmic reticulum to nucleus signaling 1.	0.426
ATF6B	HSPA5	ENSPTRP00000057131	ENSPTRP00000000984	Activating transcription factor 6 beta.	Heat shock 70kDa protein 5 (Glucose-regulated protein, 78kDa); Belongs to the heat shock protein 70 family.	0.845
ATF6B	XBP1	ENSPTRP00000057131	ENSPTRP00000065969	Activating transcription factor 6 beta.	XBP1 isoform 4.	0.789
DDIT3	ATF6	ENSPTRP00000043666	ENSPTRP00000002668	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	Activating transcription factor 6.	0.989
DDIT3	ATF6B	ENSPTRP00000043666	ENSPTRP00000057131	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	Activating transcription factor 6 beta.	0.959
DDIT3	EDEM1	ENSPTRP00000043666	ENSPTRP00000025126	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	0.484
DDIT3	ERN1	ENSPTRP00000043666	ENSPTRP00000080224	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	Endoplasmic reticulum to nucleus signaling 1.	0.616
DDIT3	HSPA5	ENSPTRP00000043666	ENSPTRP00000000984	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	Heat shock 70kDa protein 5 (Glucose-regulated protein, 78kDa); Belongs to the heat shock protein 70 family.	0.661
DDIT3	XBP1	ENSPTRP00000043666	ENSPTRP00000065969	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	XBP1 isoform 4.	0.976
EDEM1	ATF6	ENSPTRP00000025126	ENSPTRP00000002668	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	Activating transcription factor 6.	0.688