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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RAC3Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3). (205 aa)    
Predicted Functional Partners:
ITSN2
ITSN2 isoform 1.
    
 0.962
PAK1
Non-specific serine/threonine protein kinase.
   
 0.922
VAV1
Vav guanine nucleotide exchange factor 1.
   
 0.915
TRIO
Trio Rho guanine nucleotide exchange factor.
   
 0.900
DOCK10
Dedicator of cytokinesis 10; Belongs to the DOCK family.
   
 0.897
PAK4
Non-specific serine/threonine protein kinase.
   
 0.890
DOCK2
Dedicator of cytokinesis 2; Belongs to the DOCK family.
   
 0.887
DOCK5
Dedicator of cytokinesis 5; Belongs to the DOCK family.
   
 0.887
ELMO1
Engulfment and cell motility 1.
    
 0.883
PLXNB1
PLXNB1 isoform 1.
   
 0.879
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.