STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EP300E1A binding protein p300. (2175 aa)    
Predicted Functional Partners:
SP1
Sp1 transcription factor.
   
 0.999
HIF1A
Hypoxia inducible factor 1 subunit alpha.
    
 0.999
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.999
NCOA3
Nuclear receptor coactivator.
   
 0.999
KAT2B
Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily.
    
 0.999
CREB1
cAMP responsive element binding protein 1.
   
 0.999
CREBBP
CREB binding protein.
  
0.999
KAT2A
Histone acetyltransferase KAT2A isoform X1.
    
 0.998
NCOA1
Nuclear receptor coactivator.
   
 0.998
CTNNB1
Catenin (Cadherin-associated protein), beta 1, 88kDa.
    
 0.998
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.