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MYD88 protein (Pan troglodytes) - STRING interaction network
"MYD88" - Myeloid differentiation primary response protein MyD88 in Pan troglodytes
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (296 aa)    
Predicted Functional Partners:
TRAF6
TNF receptor-associated factor 6; Uncharacterized protein (522 aa)
     
  0.997
IRAK4
Interleukin-1 receptor-associated kinase 4; Uncharacterized protein (460 aa)
     
  0.997
IL1R1
Uncharacterized protein; Interleukin 1 receptor, type I (568 aa)
     
  0.996
IRAK1
Interleukin-1 receptor-associated kinase 1; Uncharacterized protein (712 aa)
     
  0.994
TLR9
Uncharacterized protein; Pan troglodytes toll-like receptor 9 (TLR9), mRNA (1032 aa)
     
  0.984
TLR4
Pan troglodytes toll-like receptor 4 (TLR4), mRNA (839 aa)
     
0.982
TLR7
Uncharacterized protein; Pan troglodytes toll-like receptor 7 (TLR7), mRNA (1048 aa)
     
  0.980
IRAK2
Uncharacterized protein; Interleukin-1 receptor-associated kinase 2 (588 aa)
       
 
  0.974
MAP3K7
Mitogen-activated protein kinase kinase kinase 7; Uncharacterized protein (606 aa)
       
  0.974
TLR6
Pan troglodytes toll-like receptor 6 (TLR6), mRNA (796 aa)
     
  0.973
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, Pan troglodytes, chimpanzee
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