CCR5 protein (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCL2	CCL3	ENSPTRP00000068745	ENSPTRP00000057009	C-C motif chemokine.	C-C motif chemokine 3; Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5 (By similarity); Belongs to the intercrine beta (chemokine CC) family.	0.911
CCL2	CCL4	ENSPTRP00000068745	ENSPTRP00000059079	C-C motif chemokine.	C-C motif chemokine.	0.962
CCL2	CCL5	ENSPTRP00000068745	ENSPTRP00000083031	C-C motif chemokine.	C-C motif chemokine.	0.971
CCL2	CCL8	ENSPTRP00000068745	ENSPTRP00000015356	C-C motif chemokine.	C-C motif chemokine.	0.972
CCL2	CCR5	ENSPTRP00000068745	ENSPTRP00000025599	C-C motif chemokine.	C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity).	0.959
CCL2	CD4	ENSPTRP00000068745	ENSPTRP00000054833	C-C motif chemokine.	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	0.836
CCL2	GNAI1	ENSPTRP00000068745	ENSPTRP00000071974	C-C motif chemokine.	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1.	0.576
CCL2	GNG2	ENSPTRP00000068745	ENSPTRP00000065345	C-C motif chemokine.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.564
CCL2	LOC455004	ENSPTRP00000068745	ENSPTRP00000088104	C-C motif chemokine.	CCL4L2 isoform 3.	0.898
CCL3	CCL2	ENSPTRP00000057009	ENSPTRP00000068745	C-C motif chemokine 3; Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5 (By similarity); Belongs to the intercrine beta (chemokine CC) family.	C-C motif chemokine.	0.911
CCL3	CCR5	ENSPTRP00000057009	ENSPTRP00000025599	C-C motif chemokine 3; Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5 (By similarity); Belongs to the intercrine beta (chemokine CC) family.	C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity).	0.979
CCL3	CD4	ENSPTRP00000057009	ENSPTRP00000054833	C-C motif chemokine 3; Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5 (By similarity); Belongs to the intercrine beta (chemokine CC) family.	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	0.799
CCL4	CCL2	ENSPTRP00000059079	ENSPTRP00000068745	C-C motif chemokine.	C-C motif chemokine.	0.962
CCL4	CCL5	ENSPTRP00000059079	ENSPTRP00000083031	C-C motif chemokine.	C-C motif chemokine.	0.471
CCL4	CCL8	ENSPTRP00000059079	ENSPTRP00000015356	C-C motif chemokine.	C-C motif chemokine.	0.452
CCL4	CCR5	ENSPTRP00000059079	ENSPTRP00000025599	C-C motif chemokine.	C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity).	0.979
CCL4	CD4	ENSPTRP00000059079	ENSPTRP00000054833	C-C motif chemokine.	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	0.693
CCL4	LOC455004	ENSPTRP00000059079	ENSPTRP00000088104	C-C motif chemokine.	CCL4L2 isoform 3.	0.900
CCL5	CCL2	ENSPTRP00000083031	ENSPTRP00000068745	C-C motif chemokine.	C-C motif chemokine.	0.971
CCL5	CCL4	ENSPTRP00000083031	ENSPTRP00000059079	C-C motif chemokine.	C-C motif chemokine.	0.471