| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APLF | CHD1L | ENSPTRP00000020613 | ENSPTRP00000070728 | Aprataxin and PNK-like factor isoform X1. | Chromodomain helicase DNA binding protein 1-like. | 0.925 |
| APLF | PARG | ENSPTRP00000020613 | ENSPTRP00000058989 | Aprataxin and PNK-like factor isoform X1. | Uncharacterized protein. | 0.424 |
| APLF | PARG-2 | ENSPTRP00000020613 | ENSPTRP00000062052 | Aprataxin and PNK-like factor isoform X1. | Poly(ADP-ribose) glycohydrolase. | 0.424 |
| APLF | PARP1 | ENSPTRP00000020613 | ENSPTRP00000003457 | Aprataxin and PNK-like factor isoform X1. | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. | 0.952 |
| APLF | PARP3 | ENSPTRP00000020613 | ENSPTRP00000025859 | Aprataxin and PNK-like factor isoform X1. | Poly [ADP-ribose] polymerase. | 0.738 |
| CASP3 | CASP7 | ENSPTRP00000054330 | ENSPTRP00000074501 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. | CASP7 isoform 1; Belongs to the peptidase C14A family. | 0.973 |
| CASP3 | CASP9 | ENSPTRP00000054330 | ENSPTRP00000089496 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. | CASP9 isoform 4; Belongs to the peptidase C14A family. | 0.998 |
| CASP3 | GZMB | ENSPTRP00000054330 | ENSPTRP00000087293 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. | GZMB isoform 2; Belongs to the peptidase S1 family. | 0.979 |
| CASP3 | PARP1 | ENSPTRP00000054330 | ENSPTRP00000003457 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. | 0.997 |
| CASP3 | PARP3 | ENSPTRP00000054330 | ENSPTRP00000025859 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. | Poly [ADP-ribose] polymerase. | 0.928 |
| CASP7 | CASP3 | ENSPTRP00000074501 | ENSPTRP00000054330 | CASP7 isoform 1; Belongs to the peptidase C14A family. | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. | 0.973 |
| CASP7 | CASP9 | ENSPTRP00000074501 | ENSPTRP00000089496 | CASP7 isoform 1; Belongs to the peptidase C14A family. | CASP9 isoform 4; Belongs to the peptidase C14A family. | 0.987 |
| CASP7 | GZMB | ENSPTRP00000074501 | ENSPTRP00000087293 | CASP7 isoform 1; Belongs to the peptidase C14A family. | GZMB isoform 2; Belongs to the peptidase S1 family. | 0.923 |
| CASP7 | PARP1 | ENSPTRP00000074501 | ENSPTRP00000003457 | CASP7 isoform 1; Belongs to the peptidase C14A family. | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. | 0.990 |
| CASP7 | PARP3 | ENSPTRP00000074501 | ENSPTRP00000025859 | CASP7 isoform 1; Belongs to the peptidase C14A family. | Poly [ADP-ribose] polymerase. | 0.928 |
| CASP9 | CASP3 | ENSPTRP00000089496 | ENSPTRP00000054330 | CASP9 isoform 4; Belongs to the peptidase C14A family. | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. | 0.998 |
| CASP9 | CASP7 | ENSPTRP00000089496 | ENSPTRP00000074501 | CASP9 isoform 4; Belongs to the peptidase C14A family. | CASP7 isoform 1; Belongs to the peptidase C14A family. | 0.987 |
| CASP9 | PARP1 | ENSPTRP00000089496 | ENSPTRP00000003457 | CASP9 isoform 4; Belongs to the peptidase C14A family. | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. | 0.970 |
| CASP9 | PARP3 | ENSPTRP00000089496 | ENSPTRP00000025859 | CASP9 isoform 4; Belongs to the peptidase C14A family. | Poly [ADP-ribose] polymerase. | 0.928 |
| CHD1L | APLF | ENSPTRP00000070728 | ENSPTRP00000020613 | Chromodomain helicase DNA binding protein 1-like. | Aprataxin and PNK-like factor isoform X1. | 0.925 |
