PARP3 protein (Pan troglodytes) - STRING interaction network

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second shell of interactors

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Known Interactions

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Predicted Interactions

gene neighborhood

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textmining

co-expression

protein homology

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Score

PARP3

Poly [ADP-ribose] polymerase. (539 aa)

Predicted Functional Partners:

CASP3

0.923

CASP7

0.923

CASP9

0.923

GZMB

0.903

PARG

0.803

PARG-2

0.803

APLF

0.762

XRCC5

0.672

CHD1L

0.638

XPC

0.619

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APLF	CHD1L	ENSPTRP00000020613	ENSPTRP00000070728	Aprataxin and PNK-like factor isoform X1.	Chromodomain helicase DNA binding protein 1-like.	0.835
APLF	PARP3	ENSPTRP00000020613	ENSPTRP00000025859	Aprataxin and PNK-like factor isoform X1.	Poly [ADP-ribose] polymerase.	0.762
APLF	XPC	ENSPTRP00000020613	ENSPTRP00000051558	Aprataxin and PNK-like factor isoform X1.	XPC complex subunit, DNA damage recognition and repair factor.	0.770
APLF	XRCC5	ENSPTRP00000020613	ENSPTRP00000022048	Aprataxin and PNK-like factor isoform X1.	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	0.987
CASP3	CASP7	ENSPTRP00000054330	ENSPTRP00000074501	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	CASP7 isoform 1; Belongs to the peptidase C14A family.	0.964
CASP3	CASP9	ENSPTRP00000054330	ENSPTRP00000089496	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	CASP9 isoform 4; Belongs to the peptidase C14A family.	0.996
CASP3	GZMB	ENSPTRP00000054330	ENSPTRP00000087293	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	GZMB isoform 2; Belongs to the peptidase S1 family.	0.966
CASP3	PARP3	ENSPTRP00000054330	ENSPTRP00000025859	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	Poly [ADP-ribose] polymerase.	0.923
CASP3	XRCC5	ENSPTRP00000054330	ENSPTRP00000022048	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	0.465
CASP7	CASP3	ENSPTRP00000074501	ENSPTRP00000054330	CASP7 isoform 1; Belongs to the peptidase C14A family.	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	0.964
CASP7	CASP9	ENSPTRP00000074501	ENSPTRP00000089496	CASP7 isoform 1; Belongs to the peptidase C14A family.	CASP9 isoform 4; Belongs to the peptidase C14A family.	0.966
CASP7	GZMB	ENSPTRP00000074501	ENSPTRP00000087293	CASP7 isoform 1; Belongs to the peptidase C14A family.	GZMB isoform 2; Belongs to the peptidase S1 family.	0.924
CASP7	PARP3	ENSPTRP00000074501	ENSPTRP00000025859	CASP7 isoform 1; Belongs to the peptidase C14A family.	Poly [ADP-ribose] polymerase.	0.923
CASP9	CASP3	ENSPTRP00000089496	ENSPTRP00000054330	CASP9 isoform 4; Belongs to the peptidase C14A family.	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	0.996
CASP9	CASP7	ENSPTRP00000089496	ENSPTRP00000074501	CASP9 isoform 4; Belongs to the peptidase C14A family.	CASP7 isoform 1; Belongs to the peptidase C14A family.	0.966
CASP9	PARP3	ENSPTRP00000089496	ENSPTRP00000025859	CASP9 isoform 4; Belongs to the peptidase C14A family.	Poly [ADP-ribose] polymerase.	0.923
CHD1L	APLF	ENSPTRP00000070728	ENSPTRP00000020613	Chromodomain helicase DNA binding protein 1-like.	Aprataxin and PNK-like factor isoform X1.	0.835
CHD1L	PARP3	ENSPTRP00000070728	ENSPTRP00000025859	Chromodomain helicase DNA binding protein 1-like.	Poly [ADP-ribose] polymerase.	0.638
CHD1L	XPC	ENSPTRP00000070728	ENSPTRP00000051558	Chromodomain helicase DNA binding protein 1-like.	XPC complex subunit, DNA damage recognition and repair factor.	0.766
GZMB	CASP3	ENSPTRP00000087293	ENSPTRP00000054330	GZMB isoform 2; Belongs to the peptidase S1 family.	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	0.966