RETNLB protein (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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structured XML interaction data, according to the 'PSI-MI' data standard

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... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADIPOQ	IL6	ENSPTRP00000027045	ENSPTRP00000068252	Adiponectin, C1Q and collagen domain containing.	Interleukin 6 (Interferon, beta 2).	0.649
ADIPOQ	INS	ENSPTRP00000027045	ENSPTRP00000077843	Adiponectin, C1Q and collagen domain containing.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.854
ADIPOQ	ITLN1	ENSPTRP00000027045	ENSPTRP00000002619	Adiponectin, C1Q and collagen domain containing.	ITLN1 isoform 1.	0.510
ADIPOQ	LEP	ENSPTRP00000027045	ENSPTRP00000072740	Adiponectin, C1Q and collagen domain containing.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...]	0.931
ADIPOQ	PPARG	ENSPTRP00000027045	ENSPTRP00000076701	Adiponectin, C1Q and collagen domain containing.	Peroxisome proliferator-activated receptor gamma isoform X2.	0.832
ADIPOQ	RETNLB	ENSPTRP00000027045	ENSPTRP00000026222	Adiponectin, C1Q and collagen domain containing.	Resistin like beta.	0.840
ADIPOQ	SERPINE1	ENSPTRP00000027045	ENSPTRP00000033420	Adiponectin, C1Q and collagen domain containing.	Serpin family E member 1; Belongs to the serpin family.	0.578
ADIPOQ	TNF	ENSPTRP00000027045	ENSPTRP00000069905	Adiponectin, C1Q and collagen domain containing.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.663
ARG1	IL6	ENSPTRP00000031753	ENSPTRP00000068252	Arginase.	Interleukin 6 (Interferon, beta 2).	0.614
ARG1	PPARG	ENSPTRP00000031753	ENSPTRP00000076701	Arginase.	Peroxisome proliferator-activated receptor gamma isoform X2.	0.415
ARG1	RETNLB	ENSPTRP00000031753	ENSPTRP00000026222	Arginase.	Resistin like beta.	0.626
ARG1	TNF	ENSPTRP00000031753	ENSPTRP00000069905	Arginase.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.644
IL6	ADIPOQ	ENSPTRP00000068252	ENSPTRP00000027045	Interleukin 6 (Interferon, beta 2).	Adiponectin, C1Q and collagen domain containing.	0.649
IL6	ARG1	ENSPTRP00000068252	ENSPTRP00000031753	Interleukin 6 (Interferon, beta 2).	Arginase.	0.614
IL6	INS	ENSPTRP00000068252	ENSPTRP00000077843	Interleukin 6 (Interferon, beta 2).	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.687
IL6	LEP	ENSPTRP00000068252	ENSPTRP00000072740	Interleukin 6 (Interferon, beta 2).	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...]	0.683
IL6	PPARG	ENSPTRP00000068252	ENSPTRP00000076701	Interleukin 6 (Interferon, beta 2).	Peroxisome proliferator-activated receptor gamma isoform X2.	0.588
IL6	RETNLB	ENSPTRP00000068252	ENSPTRP00000026222	Interleukin 6 (Interferon, beta 2).	Resistin like beta.	0.524
IL6	SERPINE1	ENSPTRP00000068252	ENSPTRP00000033420	Interleukin 6 (Interferon, beta 2).	Serpin family E member 1; Belongs to the serpin family.	0.600
IL6	TNF	ENSPTRP00000068252	ENSPTRP00000069905	Interleukin 6 (Interferon, beta 2).	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.929